{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:03:03Z","timestamp":1789639383387,"version":"4.0.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T00:00:00Z","timestamp":1635552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In some rare arrhythmia syndromes, arrhythmia risk in female patients increases during pregnancy, necessitating extra controls. We wanted to evaluate if the increased risk for arrhythmia during pregnancy applies in women with Brugada syndrome and their potentially affected fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search was performed on PubMed (MeSH search terms \u201cBrugada syndrome,\u201d\u00a0\u201cpregnancy,\u201d\u00a0\u201cparturition,\u201d\u00a0\u201clabor,\u201d\u00a0\u201cdelivery,\u201d\u00a0\u201cfetal death,\u201d and \u201cstillbirth\u201d).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, six case reports with a total of six patients were identified. Of these six patients (three carriers of an <jats:italic>SCN5A<\/jats:italic> variant, three not tested), two women (both with unknown <jats:italic>SCN5A<\/jats:italic> status), developed severe cardiac events during pregnancy. The first patient, with a previous history of aborted sudden cardiac arrest at the age of 12 years, developed ventricular fibrillation\u00a0(VF), while the other was diagnosed with Brugada syndrome postpartum because of nocturnal agonal respiration during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These (limited, heterogenous) cases suggest that women with Brugada syndrome (and their possibly affected fetuses), might have an overall low tendency to develop arrhythmias during pregnancy, but important data on risk factors (<jats:italic>SCN5A<\/jats:italic> status) are lacking. Arrhythmia risk during pregnancy seems to increase in probands and those who have previously experienced cardiac events. We suggest the use of risk stratification in these women to improve patient care, lower the emotional stress and physical burden for the pregnant mother, and lower health costs. Furthermore, we plead for <jats:italic>SCN5A<\/jats:italic> analysis in all these women for use of risk stratification and to enable cascade screening especially for specialized care in children carrying an <jats:italic>SCN5A<\/jats:italic> mutation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15279","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T13:04:05Z","timestamp":1634821445000},"page":"123-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pregnancy in women with Brugada syndrome: Is there an increased arrhythmia risk? A case\u2010series report"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8619-1511","authenticated-orcid":false,"given":"Saskia N.","family":"van der Crabben","sequence":"first","affiliation":[{"name":"Department of Clinical Genetics, Amsterdam University Medical Centers, Location AMC University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam University Medical Centers, Location AMC, Member of European Reference Network GUARD\u2010Heart University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astra I. E.","family":"Kowsoleea","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Amsterdam University Medical Centers, Location AMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally\u2010Ann B.","family":"Clur","sequence":"additional","affiliation":[{"name":"Amsterdam University Medical Centers, Location AMC, Member of European Reference Network GUARD\u2010Heart University of Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Pediatric Cardiology Amsterdam University Medical Centers, Location AMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0528-0852","authenticated-orcid":false,"given":"Arthur A. M.","family":"Wilde","sequence":"additional","affiliation":[{"name":"Amsterdam University Medical Centers, Location AMC, Member of European Reference Network GUARD\u2010Heart University of Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Cardiology, Amsterdam University Medical Centers, Location AMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa1051"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.08.004"},{"key":"e_1_2_6_4_1","first-page":"176","article-title":"The clinical significance of pregnancy in Brugada syndrome","volume":"67","author":"Rodr\u00edguez\u2010Ma\u00f1ero M","year":"2014","journal-title":"Rev Esp Cardiol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redar.2019.01.005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2018.02.008"},{"key":"e_1_2_6_7_1","first-page":"531648","article-title":"Brugada syndrome and pregnancy: highlights on antenatal and prenatal management","volume":"2014","author":"Giambanco L","year":"2014","journal-title":"Case Rep Obstet Gynecol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00399-013-0287-1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2010.10.006"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.01.066"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.06.019"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.01.048"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.09.010"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.045720"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.13752"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15279","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.15279","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T06:33:49Z","timestamp":1693204429000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.15279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,30]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/jce.15279"],"URL":"https:\/\/doi.org\/10.1111\/jce.15279","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,30]]},"assertion":[{"value":"2021-07-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}