{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T10:12:53Z","timestamp":1775211173617,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T00:00:00Z","timestamp":1642896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Septal myectomy for obstructive hypertrophic cardiomyopathy (HCM) is associated with conduction block; however, the electrophysiological characteristics of conduction block have not been well characterized. The aim of study was to assess the feasibility and safety of His bundle pacing (HBP) and left bundle branch area pacing (LBBAP) in patients with septal myectomy\u2010associated conduction block.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Patients with HCM and indications for pacing or cardiac resynchronization therapy after septal myectomy were included. Electrophysiological mapping was performed to identify the site of block. The success rates and pacing characteristics of HBP and LBBAP were also recorded. The echocardiographic data and complications were documented and tracked during follow\u2010up. Ten patients with atrioventricular block (AVB) or left bundle branch block (LBBB) post\u2010myectomy were included in the study. The site of block was infranodal in the nine patients with AVB. HBP failed due to the lack of distal His bundle capture (<jats:italic>N<\/jats:italic>\u2009=\u20097) or LBBB correction (<jats:italic>N<\/jats:italic>\u2009=\u20093). LBBAP was successful in nine patients and failed in one. QRS duration narrowed from 163.3\u2009\u00b1\u200916.6\u2009ms after surgery to 123.6\u2009\u00b1\u200915.8\u2009ms during LBBAP (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The mean depth of the leads was 13.3\u2009\u00b1\u20094.0\u2009mm (range from 10 to 20\u2009mm). At a mean follow\u2010up of 5.3\u2009\u00b1\u20093.9\u2009months, pacing parameters and left ventricular ejection fraction remained stable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Electrophysiological mapping revealed that the site of block was infra\u2010Hisian and not correctable with HBP in patients with HCM post\u2010myectomy. LBBAP appears to be a more feasible physiological strategy for these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15362","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T05:40:14Z","timestamp":1642138814000},"page":"437-445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Conduction system pacing following septal myectomy: Insights into site of conduction block"],"prefix":"10.1111","volume":"33","author":[{"given":"Rujie","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"},{"name":"The Key Lab of Cardiovascular Disease of Wenzhou Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1342-9012","authenticated-orcid":false,"given":"Yingxue","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengjie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"},{"name":"The Key Lab of Cardiovascular Disease of Wenzhou Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"},{"name":"The Key Lab of Cardiovascular Disease of Wenzhou Wenzhou 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Cardiovascular Institute, Guangdong Provincial People's Hospital Guangdong Academy of Medical Science Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2230-100X","authenticated-orcid":false,"given":"Pugazhendhi","family":"Vijayaraman","sequence":"additional","affiliation":[{"name":"Geisinger Heart Institute Geisinger Commonwealth School of Medicine Wilkes Barre Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2958-134X","authenticated-orcid":false,"given":"Weijian","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"},{"name":"The Key Lab of Cardiovascular Disease of Wenzhou Wenzhou 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