{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T20:30:08Z","timestamp":1774384208215,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T00:00:00Z","timestamp":1642896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Registry data add important information to randomized controlled trials (RCT) on real\u2010life aspects of implantable cardioverter\u2010defibrillator (ICD) patients with and without cardiac resynchronization therapy (CRT\u2010D). This analysis of the prospectively conducted German Device Registry aims at comparing mortality rates, comorbidities, complication rates to results from RCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The German Device registry (DEVICE) prospectively collected data on ICD and CRT\u2010D first implantations from 50 German centres. Demographic data, details on cardiac disease, electrocardiogram (ECG), medication, and data about procedure, complications, and hospital stay were stored in electronic case report forms. One year after device implantation patients were contacted for follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DEVICE included <jats:italic>n<\/jats:italic>\u2009=\u20094384 first ICD\/CRT\u2010D implantations (29.3% CRT\u2010D devices). We found a strong adherence to guidelines with over 90% of patients being on \u00df\u2010blocker and ACE\u2010inhibitor medication and adequate QRS width in the majority of CRT\u2010D patients. Patients receiving a CRT\u2010D were older (67.6\u2009\u00b1\u200911.0\u2009years vs. 63.9\u2009\u00b1\u200913.4\u2009years, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and had lower ejection fractions (mean 25% vs. 30%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) compared to ICD patients. Dilated cardiomyopathy was the predominant underlying heart disease in CRT\u2010D (53.3%), coronary artery disease in ICD patients (64.7%). Compared to RCT our DEVICE patients had more comorbidities (17.9% chronic kidney disease [CKD]) and higher 1\u2010year mortality rates (10.7% ICD group, 12.3% CRT group). In multivariate analysis, CKD patients had an almost 2\u2010fold higher risk of 1\u2010year mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite relevant limitations of registry data, DEVICE highlights important differences between RCT and real\u2010world registry data and the impact of comorbidities on mortality of ICD and CRT\u2010D recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15365","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T05:39:56Z","timestamp":1642138796000},"page":"483-492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Selection and outcome of implantable cardioverter\u2010defibrillator patients with and without cardiac resynchronization therapy: Comparison of 4384 patients from the German Device Registry to randomized controlled trials"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5877-352X","authenticated-orcid":false,"given":"Julia","family":"K\u00f6be","sequence":"first","affiliation":[{"name":"Division of Electrophysiology Department of Cardiology and Angiology M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1259-3213","authenticated-orcid":false,"given":"Kevin","family":"Willy","sequence":"additional","affiliation":[{"name":"Division of Electrophysiology Department of Cardiology and Angiology M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Senges","sequence":"additional","affiliation":[{"name":"Stiftung Institut f\u00fcr Herzinfarktforschung (IHF) Ludwigshafen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Hochadel","sequence":"additional","affiliation":[{"name":"Stiftung Institut f\u00fcr 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