{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:33:40Z","timestamp":1787499220587,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:00:00Z","timestamp":1643932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atrioventricular block (AVB) is an important complication following valvular surgery. Several factors including inflammation\u2010mediated injury might trigger AVB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with advanced postoperative AVB were randomly assigned to receive either dexamethasone (0.4\u2009mg\/kg, maximum 30\u2009mg\/day) intravenously for 3 days or conservative care only. Primary endpoint was recovery rate in Day 5 since randomization. Secondary endpoints were recovery rate in Day 7 and Day 10, cumulative AVB time, permanent pacemaker (PPM) implantation rate, length of stay in critical care units, and postoperative major adverse events (MAE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We enrolled 139 subjects (48.9% male) with mean age of 59.9 years randomly allocated to intervention group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200969) and control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200970). Dexamethasone led to higher recovery rates at Day 5 (82.6% vs. 62.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.009) and Day 7 (88.4% vs. 61.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001) respectively. This benefit ceased at Day 10 (83.05% vs. 78.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.547). Median cumulative AVB time was shorter in dexamethasone group compared with control group (41\u2009h vs. 64\u2009h,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.044). PPM implantation rates were similar between the dexamethasone and control groups (15.9% vs. 17.1%, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.849). Median length of stay in intensive care unit (ICU) (10 days vs. 12 days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.03) and MAE (17.4% vs. 25.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.133) tended to be lower with dexamethasone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dexamethasone may serve as a safe and effective medication to help hasten recovery of advanced AVB after valvular surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.15378","type":"journal-article","created":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T07:29:53Z","timestamp":1642922993000},"page":"575-585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Steroid Use for Recovery of advanced atrioVentricular block Immediately after VALvular surgery (SURVIVAL): A preliminary randomized clinical trial"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3079-0504","authenticated-orcid":false,"given":"Saeed","family":"Ghodsi","sequence":"first","affiliation":[{"name":"Cardiac Primary Prevention Research Center, Tehran Heart Center, Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8098-7121","authenticated-orcid":false,"given":"Farzad","family":"Masoudkabir","sequence":"additional","affiliation":[{"name":"Cardiac Primary Prevention Research Center, Tehran Heart Center, Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Cardiology, Tehran Heart Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Cardiac Primary Prevention Research Center, Tehran Heart Center, Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0544-4009","authenticated-orcid":false,"given":"Tahereh","family":"Davarpasand","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tehran Heart Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negin","family":"Yavari","sequence":"additional","affiliation":[{"name":"Cardiac Primary Prevention Research Center, Tehran Heart Center, Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrnaz","family":"Mohebi","sequence":"additional","affiliation":[{"name":"Cardiac Primary Prevention Research Center, Tehran Heart Center, Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1839-3685","authenticated-orcid":false,"given":"Azita H.","family":"Talasaz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tehran Heart Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3225-8498","authenticated-orcid":false,"given":"Arash","family":"Jalali","sequence":"additional","affiliation":[{"name":"Cardiac Primary Prevention Research Center, Tehran Heart Center, Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed H.","family":"Ahmadi\u2010Tafti","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Tehran Heart Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamshid","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Tehran Heart Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakimeh","family":"Hasanzadeh","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Tehran Heart Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.202"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.537"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69208-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2006.09.010"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEOR.S112691"},{"key":"e_1_2_8_7_1","article-title":"Valvular heart diseases\u2014epidemiology and new treatment modalities","volume":"2","author":"Osorio RC","year":"2015","journal-title":"Interv Cardiol J"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5603\/KP.a2016.0038"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2009.02170.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2018.07.012"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13291"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140340"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.5935\/1678-9741.20110010"},{"issue":"1","key":"e_1_2_8_14_1","first-page":"14","article-title":"Predictors and frequency of conduction disturbances after open\u2010heart surgery","volume":"8","author":"Emkanjoo Z","year":"2008","journal-title":"Indian Pacing Electrophysiol J"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.07.090"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/615987"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2010.249904"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.11.029"},{"issue":"8","key":"e_1_2_8_19_1","first-page":"e382","article-title":"ACC\/AHA\/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay","volume":"140","author":"Kusumoto FM","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"e_1_2_8_20_1","first-page":"164","article-title":"Atrioventricular block in coronary artery bypass surgery: perioperative predictors and impact on mortality","volume":"30","author":"Piant\u00e1 RM","year":"2015","journal-title":"Rev Bras Cir Cardiovasc"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crvasa.2017.05.017"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12202"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.848218"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2010.03.015"},{"issue":"4","key":"e_1_2_8_25_1","first-page":"657","article-title":"Steroids in cardiac surgery: a systematic review and meta\u2010analysis","volume":"120","author":"Dvirnik N","year":"2018","journal-title":"Br J Anaesth. 2018 Apr"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2015.03.009"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.18700\/jnc.170035"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00273-1"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12260"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/88.4.496"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0502-473"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(96)00095-0"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.453670"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00419"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/35059090"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15378","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.15378","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T18:56:44Z","timestamp":1692989804000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.15378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,4]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/jce.15378"],"URL":"https:\/\/doi.org\/10.1111\/jce.15378","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,4]]},"assertion":[{"value":"2021-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}