{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:00:49Z","timestamp":1761562849230,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Transvenous implantable cardioverter\u2010defibrillators (TV\u2010ICD) infection is a serious complication that frequently requires complete device removal for attempted cure, which can be associated with patient morbidity and mortality. The objective of this study is to assess mortality risk associated with TV\u2010ICD infection in a large Medicare population with de novo TV\u2010ICD implants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A survival analysis was conducted using 100% fee\u2010for\u2010service Medicare facility\u2010level claims data to identify patients who underwent de novo TV\u2010ICD implantation between 7\/2016 and 1\/2018. TV\u2010ICD infection within 2 years of implantation was identified using International Classification of Disease, 10th Edition and current procedural terminology codes. Baseline patient risk factors associated with mortality were identified using the Charlson Comorbidity Index categories. Infection was treated as a time\u2010dependent variable in a multivariate Cox proportional hazards model to account for immortal time bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 26,742 Medicare patients with de novo TV\u2010ICD, 518 (1.9%) had a device\u2010related infection. The overall number of decedents was 4721 (17.7%) over 2 years, with 4555 (17%) in the noninfection group and 166 (32%) in the infection group. After adjusting for baseline patient demographic characteristics and various comorbidities, the presence of TV\u2010ICD infection was associated with an increase of 2.4 (95% CI: 2.08\u20132.85) times in the mortality hazard ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The rate of TV\u2010ICD infection and associated mortality in a large, real\u2010world Medicare population is noteworthy. The positive association between device\u2010related infection and risk of mortality further highlights the need to reduce infections<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15385","type":"journal-article","created":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T12:30:41Z","timestamp":1642941041000},"page":"725-730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Device\u2010related infection associated with increased mortality risk in de novo transvenous implantable cardioverter\u2010defibrillator medicare patients"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4978-7177","authenticated-orcid":false,"given":"Mikhael F.","family":"El\u2010Chami","sequence":"first","affiliation":[{"name":"Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Boston Scientific Corporation Marlborough Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert I.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Boston Scientific Corporation Marlborough Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley P.","family":"Knight","sequence":"additional","affiliation":[{"name":"Center for Heart Rhythm Disorders Bluhm Cardiovascular Institute Northwestern Memorial Hospital Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1489-4028","authenticated-orcid":false,"given":"Raul","family":"Weiss","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center Cardiology, DHLRI Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George E.","family":"Mark","sequence":"additional","affiliation":[{"name":"Department of Cardiology Cooper University Hospital Camden New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Biffi","sequence":"additional","affiliation":[{"name":"Institue of Cardiology S. Orsola Malpighi Hospital Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Probst","sequence":"additional","affiliation":[{"name":"L'Institut du Thorax CHU de Nantes Cardiology Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier D.","family":"Lambiase","sequence":"additional","affiliation":[{"name":"UCL Institute of Cardiovascular Science, and Barts Heart Center London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7512-4727","authenticated-orcid":false,"given":"Marc A.","family":"Miller","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline M.","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Boston Scientific Corporation Marlborough Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry M.","family":"Baddour","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine Mayo Clinic College of Medicine and Science Rochester Minnesota USA"},{"name":"Department of Cardiovascular Diseases Mayo Clinic College of Medicine and Science Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.157182"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-6-200303180-00007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.04.033"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.116.003929"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2021.04.014"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.108.816868"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu147"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.441"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.06.031"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b5087"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12518"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/518889"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv053"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu126"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15385","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.15385","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T22:56:08Z","timestamp":1693004168000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.15385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,31]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/jce.15385"],"URL":"https:\/\/doi.org\/10.1111\/jce.15385","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"type":"print","value":"1045-3873"},{"type":"electronic","value":"1540-8167"}],"subject":[],"published":{"date-parts":[[2022,1,31]]},"assertion":[{"value":"2021-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}