{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:52:12Z","timestamp":1790344332567,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Different methods are used for atrial fibrillation (AF) cycle length (CL) measurement with variable results. Previous studies of pulmonary vein (PV) CL measurement showed contradictory results on predicting PV isolation (PVI) efficacy. A novel simple method of measuring the average of 10 consecutive Fastest Atrial Repetitive Similar morphology signal (FARS<jats:sub>10<\/jats:sub>)\u2010CL to characterize local atrial activity rate was evaluated prospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The intra\u2010observer reproducibility of FARS<jats:sub>10<\/jats:sub>\u2010CL and traditional AF\u2010CL measurement of continuously fragmented coronary sinus (CS) signals were tested. We prospectively enrolled 100 consecutive patients (62\u2009\u00b1\u200910 years, 72% male) undergoing wide antral PVI only ablation for persistent AF, measured PV\u2010FARS<jats:sub>10<\/jats:sub>\u2010CLs, and evaluated long\u2010term outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Kendall area correlation between repeated traditional AF\u2010CL measurements was \u22120.006 and between repeated FARS<jats:sub>10<\/jats:sub>\u2010CL measurements in the right and left atrial appendages, CS and PVs were 0.944, 0.859, 0.882, 0.675\u20130.955, respectively. Patients with recurrent atrial tachyarrhythmia had significantly longer fastest PV\u2010FARS<jats:sub>10<\/jats:sub>\u2010CL (172\u2009\u00b1\u200941 vs. 156\u2009\u00b1\u200941\u2009ms, <jats:italic>p<\/jats:italic>\u2009=\u2009.047). Patients with high burden of spontaneous low\u2010voltage zone (LVZ) had significantly longer fastest PV\u2010FARS<jats:sub>10<\/jats:sub>\u2010CL. Freedom from recurrent tachyarrhythmia at 24 months was 85% versus 59% in patients with fastest PV\u2010FARS<jats:sub>10<\/jats:sub>\u2010CL\u2009\u2264\u2009140 versus &gt;140\u2009ms, <jats:italic>p<\/jats:italic>\u2009=\u2009.0018, respectively. In multivariable analysis fastest PV\u2010FARS<jats:sub>10<\/jats:sub>\u2010CL\u2009\u2264\u2009140\u2009ms was the only significant predictor of freedom from recurrent tachyarrhythmia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FARS<jats:sub>10<\/jats:sub>\u2010CL measurements have a high reproducibility in contrast to traditional AF\u2010CL measurement of continuously fragmented CS signals. Patients with high burden of LVZ have longer fastest PV\u2010FARS<jats:sub>10<\/jats:sub>\u2010CLs. Fastest PV\u2010FARS<jats:sub>10<\/jats:sub>\u2010CL\u2009\u2264\u2009140\u2009ms is associated with a high success of wide antral PVI\u2010only ablation approach in persistent AF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15401","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T04:13:22Z","timestamp":1644293602000},"page":"641-650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Reproducibility and predictive value of a simple novel method to measure atrial fibrillation cycle length in persistent atrial fibrillation \u2013 FARS\u2010AF study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1640-9428","authenticated-orcid":false,"given":"Francesco","family":"Spera","sequence":"first","affiliation":[{"name":"Department of Cardiology University Hospital Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moises","family":"Rodriguez\u2010Ma\u00f1ero","sequence":"additional","affiliation":[{"name":"Department of\u00a0Cardiology Hospital Universitario Santiago de Compostela,\u00a0IDIS, CIBERCV  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Baluja","sequence":"additional","affiliation":[{"name":"Critical Patient Translational Research Group, Department of Anesthesiology, Intensive Care and Pain Management Hospital Cl\u00ednico Universitario  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Saenen","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Huybrechts","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hielko","family":"Miljoen","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2700-2543","authenticated-orcid":false,"given":"Maxime","family":"Tijskens","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lien","family":"Vandaele","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"Wittock","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University Hospital Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc J.","family":"Claeys","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Antwerp  Antwerp Belgium"},{"name":"University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hein","family":"Heidbuchel","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Antwerp  Antwerp Belgium"},{"name":"University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6327-0487","authenticated-orcid":false,"given":"Andrea","family":"Sarkozy","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Antwerp  Antwerp Belgium"},{"name":"University of Antwerp  Antwerp 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