{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:20:25Z","timestamp":1793337625725,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>A wearable cardioverter defibrillator (WCD) is indicated in appropriate patients to reduce the risk for sudden cardiac death. Challenges for patients wearing a WCD have been frequent false shock alarms primarily due to electrocardiogram\u00a0noise and wear discomfort. The objective of this study was to test a contemporary WCD designed for reduced false shock alarms and improved comfort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and thirty\u00a0patients with left ventricular ejection fraction\u00a0\u226440% and an active implantable cardioverter defibrillator (ICD) were fitted with the ASSURE WCD (Kestra Medical Technologies) and followed for 30 days. WCD detection was enabled and shock alarm markers recorded, but shocks and shock alarms were disabled. All WCD episodes and ICD ventricular tachycardia\/ventricular fibrillation (VT\/VF) episodes were adjudicated. The primary endpoint was the false\u2010positive shock alarm rate with a performance goal of 1 every 3.4 days (0.29 per patient\u2010day).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 163 WCD episodes, 4 were VT\/VF and 159 non\u2010VT\/VF (121 rhythms with noise, 32 uncertain with noise, 6 atrial flutter without noise). Only three false\u2010positive shock alarm markers were recorded; one false\u2010positive shock alarm every\u00a01333 patient\u2010days (0.00075 per patient\u2010day, 95% confidence interval: 0.00015\u20130.00361; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). No ICD recorded VT\/VF episodes meeting WCD detection criteria (\u2265170\u2009bpm for \u226520\u2009s) were missed by the WCD during 3501 patient\u2010days of use. Median wear was 31.0 days (interquartile range [IQR] 2.0) and median daily use 23.0\u2009h (IQR 1.7). Adverse events were mostly mild: skin irritation (19.4%) and musculoskeletal discomfort (8.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The ASSURE WCD demonstrated a low false\u2010positive shock alarm rate, low patient\u2010reported discomfort, and no serious adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15417","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T06:47:25Z","timestamp":1645080445000},"page":"831-842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A wearable cardioverter defibrillator with a low false alarm rate"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8481-7389","authenticated-orcid":false,"given":"Jeanne E.","family":"Poole","sequence":"first","affiliation":[{"name":"University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marye J.","family":"Gleva","sequence":"additional","affiliation":[{"name":"Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0473-1826","authenticated-orcid":false,"given":"Ulrika","family":"Birgersdotter\u2010Green","sequence":"additional","affiliation":[{"name":"University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley R. H.","family":"Branch","sequence":"additional","affiliation":[{"name":"University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul N.","family":"Doshi","sequence":"additional","affiliation":[{"name":"Honor Health  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0829-8505","authenticated-orcid":false,"given":"Tariq","family":"Salam","sequence":"additional","affiliation":[{"name":"Pulse Heart Institute  Tacoma Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Crawford","sequence":"additional","affiliation":[{"name":"University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Willcox","sequence":"additional","affiliation":[{"name":"Alaska Heart and Vascular Institute  Anchorage Alaska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun M.","family":"Sridhar","sequence":"additional","affiliation":[{"name":"University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghiath","family":"Mikdadi","sequence":"additional","affiliation":[{"name":"Heart Clinic of Hammond Center for Cardiac and Vascular Research  Hammond Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean C.","family":"Beinart","sequence":"additional","affiliation":[{"name":"Washington Adventist Healthcare White Oak Medical Center  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5897-9464","authenticated-orcid":false,"given":"Yong\u2010Mei","family":"Cha","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M","family":"Russo","sequence":"additional","affiliation":[{"name":"Cooper Medical School of Rowan University  Camden New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron K.","family":"Rowbotham","sequence":"additional","affiliation":[{"name":"Kestra Medical Technologies, Inc.  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