{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:28:51Z","timestamp":1789241331293,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>High power short duration (HPSD) ablation proved to be an effective and safe ablation technique for atrial fibrillation (AF). In former case series, a significant amount of postablation coagulation at the catheter tip as well as silent cerebral lesions (SCL) in postprocedural cerebral magnetic resonance (cMRI) have been identified in patients undergoing de\u2010novo AF ablations with very high power 90\u2009W short duration (vHPvSD) ablations using the QDot ablation catheter in combination with a novel RF generator (nGEN, Biosense Webster). Therefore, the RF generator software has been recently modified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      Consecutive patients undergoing a first AF ablation including pulmonary vein isolation (PVI) with vHPvSD (90\u2009W, with a predefined ablation time of 3\u2009s at posterior left atrium (LA) wall sites and 4\u2009s at other ablation sites) using the QDOT Micro ablation catheter (Biosense Webster) in conjunction with the technically modified nGEN RF generator (software V1c; Biosense Webster) were included. Procedural characteristics including first\u2010pass isolation per pulmonary vein (PV) pair and early reconnection location within the 30\u2010min\u00a0waiting period were recorded. In all patients postablation endoscopy to document any thermal esophageal injury (EDEL) and in eligible patients a cMRI to detect silent cerebral events (SCEs)\/lesions\u00a0were performed. All acute procedure\u2010related complications were recorded during the time until hospital discharge. Furthermore, short\u2010term and midterm success after 3 and 6\u201312 months of follow\u2010up was investigated. In total, 34 consecutive patients (67\u2009\u00b1\u20099 years; 62% male; 68% paroxysmal AF) were included. First\u2010pass isolation of all PVs was achieved in 6\/34 (18%) patients. First\u2010pass isolation was seen in 37\/68 (54%) of PV pairs. Early reconnection occurred in 11 (32%) patients (including reconnections at posterior LA wall sites\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096 and at nonposterior sites\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095). No patient had an EDEL (0%). In 6\/23 (26%) patients undergoing postablation cerebral MRI SCEs were identified. In six patients, coagulation on the catheter tip was detected at the end of the procedure. No further peri\u2010 or postprocedural complications were detected. Early AF recurrence before discharge was seen in 1\/34 (3%) of the patients included in this study. Within 3 months 10\/34 (29%) revealed AF recurrence during blanking period. After a mean follow\u2010up of 7 months, 31\/34 (88%) patients revealed sinus rhythm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AF ablation using 90\u2009W vHPvSD with a specialized ablation catheter in conjunction with a recently modified RF generator was associated with no EDEL in the whole study cohort and 26% SCEs in a subgroup of patients undergoing acute postablation cerebral MRI. Accordingly, to our previously published results, a relevant number of catheter tip coagulations was identified in this patient cohort even after modifications of the RF generator. The vHPvSD ablation technique using the present and the previous generator seems to be associated with a very low rate of esophageal injury. However, the recently revised generator software also produced a relevant number of catheter tip coagulum formation and SCEs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.15433","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T04:18:25Z","timestamp":1646194705000},"page":"920-927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Safety aspects of very high power very short duration atrial fibrillation ablation using a modified radiofrequency RF\u2010generator: Single\u2010center experience"],"prefix":"10.1111","volume":"33","author":[{"given":"Julian","family":"Mueller","sequence":"first","affiliation":[{"name":"Clinic for Invasive Electrophysiology Heart Center Bad Neustadt  Bad Neustadt a.d. Saale Germany"},{"name":"Department of Cardiology and Angiology Philipps\u2010University Marburg  Marburg Germany"},{"name":"First Department of Medicine University Medical Centre Mannheim Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4291-2417","authenticated-orcid":false,"given":"Philipp","family":"Halbfass","sequence":"additional","affiliation":[{"name":"Clinic for Invasive Electrophysiology Heart Center Bad Neustadt  Bad Neustadt a.d. Saale Germany"},{"name":"Department of Cardiology and Angiology Philipps\u2010University Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Sonne","sequence":"additional","affiliation":[{"name":"Clinic for Invasive Electrophysiology Heart Center Bad Neustadt  Bad Neustadt a.d. Saale Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Nentwich","sequence":"additional","affiliation":[{"name":"Clinic for Invasive Electrophysiology Heart Center Bad Neustadt  Bad Neustadt a.d. Saale Germany"},{"name":"Department of Cardiology and Angiology Philipps\u2010University Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ene","sequence":"additional","affiliation":[{"name":"Clinic for Invasive Electrophysiology Heart Center Bad Neustadt  Bad Neustadt a.d. Saale Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Berkovitz","sequence":"additional","affiliation":[{"name":"Clinic for Invasive Electrophysiology Heart Center Bad Neustadt  Bad Neustadt a.d. Saale Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Lehmkuhl","sequence":"additional","affiliation":[{"name":"Clinic for Radiology Heart Center Bad Neustadt a.d. Saale Bad Neustadt a.d. Saale Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Barth","sequence":"additional","affiliation":[{"name":"Clinic for Invasive Electrophysiology Heart Center Bad Neustadt  Bad Neustadt a.d. Saale Germany"},{"name":"Department of Cardiology and Angiology Philipps\u2010University Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gelu R.","family":"Simu","sequence":"additional","affiliation":[{"name":"Clinic for Invasive Electrophysiology Heart Center Bad Neustadt  Bad Neustadt a.d. Saale Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1558-0696","authenticated-orcid":false,"given":"Christian","family":"Waechter","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology Philipps\u2010University Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5970-0093","authenticated-orcid":false,"given":"Michael","family":"Behnes","sequence":"additional","affiliation":[{"name":"First Department of Medicine University Medical Centre Mannheim Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Deneke","sequence":"additional","affiliation":[{"name":"Clinic for Invasive Electrophysiology Heart Center Bad Neustadt  Bad Neustadt a.d. Saale Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028981"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.09.027"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2019.04.009"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euab261"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux376"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.117.005233"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euz342"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14219"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-018-0322-6"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000612"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2018.08.003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaa081"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euy121"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2020.05.029"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13471"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15433","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.15433","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T22:50:52Z","timestamp":1692831052000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.15433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,11]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/jce.15433"],"URL":"https:\/\/doi.org\/10.1111\/jce.15433","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,11]]},"assertion":[{"value":"2021-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}