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A diagnosis of early repolarization syndrome (ERS) was made with an early repolarization pattern on electrocardiogram, documented VT episodes, and clinical presyncope (proposed Shanghai score 7). Paroxysmal atrial fibrillation (AF) was also noted on 24\u2010h Holter recordings. The child was stabilized with isoprenaline infusion and was later discharged with arrhythmia control on quinidine and cilostazol. The genetic evaluation revealed a potassium channel <jats:italic>KCND3<\/jats:italic> gene missense mutation. The case highlights the association of epilepsy syndrome and AF with ERS; the possible association of <jats:italic>KCND3<\/jats:italic> gene mutation with a malignant phenotype; and management issues in a small child.<\/jats:p>","DOI":"10.1111\/jce.15489","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T09:50:24Z","timestamp":1649325024000},"page":"1312-1315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Early repolarization syndrome, epilepsy, and atrial fibrillation in a young girl with novel <i>KCND3<\/i> mutation managed with quinidine"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5486-3229","authenticated-orcid":false,"given":"Mrigank","family":"Choubey","sequence":"first","affiliation":[{"name":"All India Institute of Medical Sciences  New Delhi 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