{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:04:41Z","timestamp":1758121481647,"version":"3.37.3"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The Respiratory Disturbance Index (RDI) computed by an implantable cardioverter defibrillator (ICD) algorithm accurately identifies severe sleep apnea (SA). In the present analysis, we tested the hypothesis that RDI could also predict atrial fibrillation (AF) burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with ejection fraction \u226435% implanted with an ICD were enrolled and followed up for 24 months. One month after implantation, patients underwent a polysomnographic study. The weekly mean RDI value was considered, as calculated during the entire follow\u2010up period and over a 1\u2010week period preceding the sleep study. The endpoints were as follows: daily AF burden of \u22655\u2009min, \u22656\u2009h, \u226523\u2009h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Here, 164 patients had usable RDI values during the entire follow\u2010up period. Severe SA (RDI\u2009\u2265\u200930 episodes\/h) was diagnosed in 92 (56%) patients at the time of the sleep study. During follow\u2010up, AF burden\u2009\u2265\u20095\u2009min\/day was documented in 70 (43%), \u22656\u2009h\/day in 48 (29%), and \u226523\u2009h\/day in 33 (20%) patients. Device\u2010detected RDI\u2009\u2265\u200930 episodes\/h at the time of the polygraphy, as well as the polygraphy\u2010measured apnea hypopnea index\u2009\u2265\u200930 episodes\/h, were not associated with the occurrence of the endpoints, using a Cox regression model. However, using a time\u2010dependent model, continuously measured weekly mean RDI\u2009\u2265\u200930 episodes\/h was independently associated with AF burden\u2009\u2265\u20095\u2009min\/day (hazard ratio [HR]: 2.13, 95% confidence interval [CI]: 1.24\u20133.65, <jats:italic>p<\/jats:italic>\u2009=\u2009.006), \u22656\u2009h\/day (HR: 2.75, 95% CI: 1.37\u20135.49, <jats:italic>p<\/jats:italic>\u2009=\u2009.004), and \u226523\u2009h\/day (HR: 2.26, 95% CI: 1.05\u20134.86, <jats:italic>p<\/jats:italic>\u2009=\u2009.037).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In heart failure patients, ICD\u2010diagnosed severe SA on follow\u2010up data review identifies patients who are from two\u2010 to three\u2010fold more likely to experience an AF episode, according to various thresholds of daily AF burden.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15506","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T16:19:32Z","timestamp":1651508372000},"page":"1472-1479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between implantable defibrillator\u2010detected sleep apnea and atrial fibrillation: The DASAP\u2010HF study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9820-4815","authenticated-orcid":false,"given":"Giuseppe","family":"Boriani","sequence":"first","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, Cardiology Division University of Modena and Reggio Emilia Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3823-3809","authenticated-orcid":false,"given":"Igor","family":"Diemberger","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine, Institute of Cardiology, Policlinico S.Orsola\u2010Malpighi, University of Bologna IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ennio C. L.","family":"Pisan\u00f2","sequence":"additional","affiliation":[{"name":"Cardiology Division Vito Fazzi Hospital Lecce Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Pieragnoli","sequence":"additional","affiliation":[{"name":"Cardiology Division University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Cardiology Division \u201cBolognini\u201d Hospital Seriate BG Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Capucci","sequence":"additional","affiliation":[{"name":"Clinica di Cardiologia e Aritmologia Universit\u00e0 Politecnica delle Marche Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonello","family":"Talarico","sequence":"additional","affiliation":[{"name":"Cardiology Division Ospedale SS. Annunziata Cosenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Zecchin","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Ospedali Riuniti University of Trieste Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Rapacciuolo","sequence":"additional","affiliation":[{"name":"Cardiology Division Federico II University Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Piacenti","sequence":"additional","affiliation":[{"name":"Cardiology Division, Institute of Life Science Scuola Superiore Sant'Anna and Fondazione Toscana Gabriele Monasterio Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciro","family":"Indolfi","sequence":"additional","affiliation":[{"name":"Division of Cardiology \u201cMagna Graecia\u201d University Catanzaro Italy"},{"name":"Mediterranea Cardiocentro Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Arias","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit Hospital Virgen de la Salud Toledo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catia","family":"Checchinato","sequence":"additional","affiliation":[{"name":"Cardiology Division Ospedale Santa Croce Moncalieri TO Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria T.","family":"La Rovere","sequence":"additional","affiliation":[{"name":"Division of Cardiac Rehabilitation, Istituti Clinici Scientifici Maugeri, IRCCS Istituto Scientifico di Montescano Montescano Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Sinagra","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Ospedali Riuniti University of Trieste Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Emdin","sequence":"additional","affiliation":[{"name":"Cardiology Division, Institute of Life Science Scuola Superiore Sant'Anna and Fondazione Toscana Gabriele Monasterio Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato P.","family":"Ricci","sequence":"additional","affiliation":[{"name":"Italian Heart Rhythm Society (AIAC) Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"D'Onofrio","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Elettrofisiologia, Studio e Terapia delle Aritmie Ospedale Monaldi Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1016\/j.ejheart.2006.08.003"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1161\/01.CIR.0000068337.25994.21"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1378\/chest.122.2.558"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1016\/j.ejim.2019.07.020"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1161\/01.CIR.0000136587.68725.8E"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.1111\/j.1540-8159.2006.00496.x"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.1016\/j.hrthm.2017.09.038"},{"issue":"36","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1093\/eurheartj\/ehv316","article-title":"2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). 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