{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:44:43Z","timestamp":1779929083271,"version":"3.53.1"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Cryoballoon\u2010guided pulmonary vein isolation (CB\u2010PVI) for symptomatic atrial fibrillation (AF) has become an established treatment option with encouraging results in terms of safety and efficacy. Data reporting on long\u2010term data beyond a follow\u2010up (FU) period of 5 years is scarce. This prospective study aimed to evaluate very long\u2010term outcome after CB\u2010PVI for AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from consecutive patients treated with CB\u2010PVI for symptomatic and drug refractory AF between 2005 and 2012 were analyzed. Patients with a FU of \u22659 years after index CB\u2010PVI were included. All patients were continuously followed\u2010up in our outpatient clinic. Arrhythmia recurrence was defined as AF or atrial tachycardia (AT) lasting &gt;30\u2009s beyond a 3\u2010month blanking period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 385 patients (71% male) were included. Mean age was 58\u2009\u00b1\u200910 years and paroxysmal AF was present in 93% of patients. Mean FU duration was 124\u2009\u00b1\u200924 months. At the end of the observational period, 73% of all patients were in stable sinus rhythm after a mean of 2\u2009\u00b1\u20090.8 ablation procedures. Patients with AF\/AT recurrence were older (60\u2009\u00b1\u20098 vs. 57\u2009\u00b1\u200910 years; <jats:italic>p<\/jats:italic>\u2009=\u2009.019), had a higher CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010Vasc Score (2.47\u2009\u00b1\u20091.46 vs. 1.98\u2009\u00b1\u20091.50; <jats:italic>p<\/jats:italic>\u2009=\u2009.01) and presented with a larger left atrium (LA)\u2010diameter (43\u2009\u00b1\u20095.6 vs. 40\u2009\u00b1\u20095.1\u2009mm; <jats:italic>p<\/jats:italic>\u2009=\u2009.002). The LA\u2010diameter was also a significant predictor for AF\/AT recurrence after CB\u2010PVI (odds ratio: 0.939, 95% confidence interval: [0.886, 0.992], <jats:italic>p<\/jats:italic>\u2009=\u2009.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CB\u2010PVI as index procedure for AF ablation resulted in favorable long\u2010term outcome in symptomatic AF. CB\u2010PVI might be recommended as interventional therapy in patients with lower LA remodeling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15512","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T10:18:10Z","timestamp":1651573090000},"page":"1383-1390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A frozen decade: Ten years outcome of atrial fibrillation ablation using a single shot device for pulmonary vein isolation"],"prefix":"10.1111","volume":"33","author":[{"given":"Leonard","family":"Bergau","sequence":"first","affiliation":[{"name":"Clinic for Electrophysiology, Herz\u2010 und Diabeteszentrum NRW Ruhr\u2010Universit\u00e4t Bochum  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Sciacca","sequence":"additional","affiliation":[{"name":"Clinic for Electrophysiology, Herz\u2010 und Diabeteszentrum NRW Ruhr\u2010Universit\u00e4t Bochum  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinitha","family":"Nesapiragasan","sequence":"additional","affiliation":[{"name":"Clinic for Electrophysiology, Herz\u2010 und Diabeteszentrum NRW Ruhr\u2010Universit\u00e4t Bochum  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Rubarth","sequence":"additional","affiliation":[{"name":"Institute of Biometry and Clinical Epidemiology Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Berlin Institute of Health at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Konietschke","sequence":"additional","affiliation":[{"name":"Institute of Biometry and Clinical Epidemiology Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Berlin Institute of Health at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Fink","sequence":"additional","affiliation":[{"name":"Clinic for Electrophysiology, Herz\u2010 und Diabeteszentrum NRW Ruhr\u2010Universit\u00e4t Bochum  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha","family":"El Hamriti","sequence":"additional","affiliation":[{"name":"Clinic for Electrophysiology, Herz\u2010 und Diabeteszentrum NRW Ruhr\u2010Universit\u00e4t Bochum  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guram","family":"Imnadze","sequence":"additional","affiliation":[{"name":"Clinic for Electrophysiology, Herz\u2010 und Diabeteszentrum NRW Ruhr\u2010Universit\u00e4t Bochum  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0660-318X","authenticated-orcid":false,"given":"Lilas","family":"Dagher","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tulane University School of Medicine  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Braun","sequence":"additional","affiliation":[{"name":"Clinic for Electrophysiology, Herz\u2010 und Diabeteszentrum NRW Ruhr\u2010Universit\u00e4t Bochum  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moneeb","family":"Khalaph","sequence":"additional","affiliation":[{"name":"Clinic for Electrophysiology, Herz\u2010 und Diabeteszentrum NRW Ruhr\u2010Universit\u00e4t Bochum  Bad Oeynhausen 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