{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T04:39:16Z","timestamp":1786336756936,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T00:00:00Z","timestamp":1651968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The iCLAS ultra\u2010low temperature cryoablation (ULTC) system has recently been brought to the market. A combination of a newly exploited cryogen and interchangeable stylet enables flexible and continuous lesion creation in atrial fibrillation (AF) ablation. The use of an esophageal warming balloon is recommended when using the system to reduce the potential for collateral esophageal injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the initial clinical experience when using ULTC in the AF treatment without general anesthesia (GA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients undergoing AF ablation using ULTC under deep sedation without GA were enrolled. We assessed the procedural data focusing on \u201csingle\u2010shot isolation\u201d defined as successful pulmonary vein (PV) isolation after the first application. Esophagogastroduodenoscopy was systematically performed the day after ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 27 AF patients (67% paroxysmal AF) were analyzed. Onehundred\u00a0four out of 106 PVs (98.1%) were isolated solely using ULTC. The mean procedure time was 79\u2009\u00b1\u200930\u2009min. The mean number of applications per PV was 2.6\u2009\u00b1\u20091.0. Single\u2010shot isolation was achieved in 57 PVs (54%) varying across PVs from left superior\u00a0to inferior PVs (40%\u201364%). The single procedure 6\u2010month recurrence\u2010free rate was 84%. No major complication (cerebrovascular event, pericardial effusion\/tamponade, esophageal damage on esophagogastroduodenoscopy) occurred. A single transient phrenic nerve palsy occurred during the right superior PV ablation, which had recovered by the 3\u2010month follow\u2010up appointment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AF ablation using the novel ULTC system seemed feasible without GA and enabled a &gt;50% single\u2010shot isolation rate. The promising safety profile has to be confirmed in large\u2010scale\u00a0studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15519","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T08:58:35Z","timestamp":1651309115000},"page":"1371-1379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Initial clinical experience of pulmonary vein isolation using the ultra\u2010low temperature cryoablation catheter for patients with atrial fibrillation"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0299-362X","authenticated-orcid":false,"given":"Shota","family":"Tohoku","sequence":"first","affiliation":[{"name":"Cardioangiologisches Centrum Bethanien Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5347-9906","authenticated-orcid":false,"given":"Boris","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Cardioangiologisches Centrum Bethanien Frankfurt Germany"},{"name":"Universit\u00e4tsklinikum Frankfurt Medizinische Klinik 3\u2010 Klinik f\u00fcr Kardiologie Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0282-4658","authenticated-orcid":false,"given":"Stefano","family":"Bordignon","sequence":"additional","affiliation":[{"name":"Cardioangiologisches Centrum Bethanien Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7082-9573","authenticated-orcid":false,"given":"Shaojie","family":"Chen","sequence":"additional","affiliation":[{"name":"Cardioangiologisches Centrum Bethanien Frankfurt Germany"},{"name":"Die Sektion Medizin Universit\u00e4t zu L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7922-3244","authenticated-orcid":false,"given":"Fabrizio","family":"Bologna","sequence":"additional","affiliation":[{"name":"Cardioangiologisches Centrum Bethanien Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2355-6015","authenticated-orcid":false,"given":"Julian Kyoung\u2010Ryul","family":"Chun","sequence":"additional","affiliation":[{"name":"Cardioangiologisches Centrum Bethanien Frankfurt Germany"},{"name":"Die Sektion Medizin Universit\u00e4t zu L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaa406"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602014"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.120.009294"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14900"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14907"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15142"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2019.0226"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12181-017-0179-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14567"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.120.009544"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2021.1990754"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13698"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-018-0474-4"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12986"},{"key":"e_1_2_7_17_1","unstructured":"VermaA DerejkoP et al. Pulsed field cryoablation (PFCA) for treatment of atrial fibrillation. AF Symposium;\u00a02022."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.121.010516"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.01.047"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2005.00216.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000131866.44650.46"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15519","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.15519","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:53:45Z","timestamp":1692838425000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.15519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,8]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/jce.15519"],"URL":"https:\/\/doi.org\/10.1111\/jce.15519","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,8]]},"assertion":[{"value":"2022-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}