{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:00:46Z","timestamp":1789826446857,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While there is recent data suggesting an advantage of computed tomography angiography (CTA) over transesophageal echocardiography (TEE) for preprocedural left atrial appendage closure (LAAC) planning, there is limited published experience for sizing strategies. Device sizing for LAAC may be challenging and noninvasive algorithms that improve this selection process are warranted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to evaluate the safety and the feasibility for the implementation of a novel CTA\u2010based sizing methodology for WATCHMAN\u2122 FLX device in a series of patients undergoing LAAC using the TruPlan\u2122 software package.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective analysis of 136 consecutive patients who underwent LAAC over a 12\u2010month period in a single, large academic hospital in the United States was conducted. CTA\u2010guided preprocedural planning and intracardiac echocardiography (ICE) was performed in all. Procedural success, adverse events, length of procedure, number of devices used, and length of stay were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 136 patients who underwent LAAC procedure with WATCHMAN\u2122 FLX platform between October 1, 2020 until September 30, 2021 were included. The pre\u2010specified protocol using CTA and ICE was implemented in all patients (100%). Mean CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>VASc score was 4.4\u2009\u00b1\u20091.3 and the mean HAS\u2010BLED score was 3.9\u2009\u00b1\u20090.8. ICE\u2010guided 100% transseptal puncture success rate was 100% with 98.5% of overall procedural success rate. Preprocedural CTA sizing strategy accurately predicted the implanted size in 91.1% of patients. Ten patients (7.4%) required another sized device and 2 cases were aborted. At 45\u2010day follow\u2010up, only 1 patient (0.7%) had significant peri\u2010device leak (\u22655\u2009mm) on TEE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CTA\u2010based preprocedural sizing methodology for WATCHMAN\u2122 FLX in LAAC was safe, feasible and associated with excellent procedural outcomes. Further studies are warranted to confirm if the features specific to TruPlan\u2122 may reduce the number of deployment attempts, the number of devices utilized in the procedure, and the risk of complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15548","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T06:50:25Z","timestamp":1652943025000},"page":"1781-1787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Novel computed tomography angiography\u2010based sizing methodology for WATCHMAN FLX device in left atrial appendage closure"],"prefix":"10.1111","volume":"33","author":[{"given":"Luis Augusto Palma","family":"Dallan","sequence":"first","affiliation":[{"name":"Division of Cardiology, Harrington Heart &amp; Vascular Institute University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Arruda","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Harrington Heart &amp; Vascular Institute University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Han","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Harrington Heart &amp; Vascular Institute University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Atif","family":"Rana","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Harrington Heart &amp; Vascular Institute University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhil","family":"Mogalapalli","sequence":"additional","affiliation":[{"name":"Department of Medicine University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman A.","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Harrington Heart &amp; Vascular Institute University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Reed","sequence":"additional","affiliation":[{"name":"Department of Medicine University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Rashid","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Harrington Heart &amp; Vascular Institute University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Rajagopalan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Harrington Heart &amp; Vascular Institute University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8364-1732","authenticated-orcid":false,"given":"Steven J.","family":"Filby","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Harrington Heart &amp; Vascular Institute University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v7.i2.65"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.029"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.976449"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.07.038"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2021.01.009"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.021"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-016-1050-6"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12909"},{"issue":"11","key":"e_1_2_9_10_1","first-page":"E851","article-title":"Left atrial appendage occlusion using cardiac CT angiography and intracardiac echocardiography: a prospective, single\u2010center study","volume":"33","author":"Filby SJ","year":"2021","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.15-195"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.08.054"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus413"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29376"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0218492314548231"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.01.175"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.07.043"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.06.056"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2017.11.012"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew212"},{"key":"e_1_2_9_21_1","first-page":"E124","article-title":"Safety, Efficacy, and Cost\u2010Effectiveness of Same\u2010Day Discharge for Left Atrial Appendage Occlusion","volume":"34","author":"Dallan LAP","year":"2022","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.10.010"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.119.007257"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.09.064"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15548","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.15548","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15548","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T11:21:58Z","timestamp":1692789718000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.15548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,26]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/jce.15548"],"URL":"https:\/\/doi.org\/10.1111\/jce.15548","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,26]]},"assertion":[{"value":"2021-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}