{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:36:24Z","timestamp":1791336984444,"version":"4.3.1"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007497","name":"Biosense Webster","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Since the widespread availability of contact\u2010force sensing catheters, the need for a waiting period after pulmonary vein isolation (PVI) has not been reassessed. We aim to evaluate whether a waiting period is still necessary after PVI guided by the ablation Index (AI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective, multicenter, randomized study of consecutive patients referred for paroxysmal atrial fibrillation (AF) ablation from May 2019 to February 2020. Patients were randomized in a 1:1 ratio to PVI with versus without a waiting period of 20\u2009min. Acute pulmonary vein (PV) reconnection after adenosine challenge was the primary endpoint. A per\u2010protocol analysis was designed to determine whether a strategy of dismissing the waiting period after PVI was noninferior to waiting for 20\u2009min for identifying acute PV reconnection. PVI was guided by tailored AI values and an interlesion distance \u22646\u2009mm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the enrollment period, 167 patients (56% males, mean age of 57\u2009\u00b1\u200914 years) fulfilled the study inclusion criteria \u2013 84 patients (308 PV) in the waiting period group (Group A) and 83 patients (314 PV) in the group without a waiting period (Group B). Acute PV reconnection was identified in 3.8% (95% confidence interval [CI], 1.7%\u20135.9%) of PVs in the study group B compared to 2.9% (95% CI, 1.0%\u20134.8%) of PVs in the Group A (<jats:italic>p<\/jats:italic>\u2009=\u2009.002 for non\u2010inferiority). At 1\u2010year follow\u2010up, there was no significant difference in arrhythmia recurrence between groups (9.5% in Group A vs. 9.6% in Group B, hazard ratio: 1.03 [95% CI, 0.39\u20132.73], <jats:italic>p<\/jats:italic>\u2009=\u2009.98).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In paroxysmal AF patients submitted to ablation, a tailored PVI guided by the AI rendered a 20\u2010min\u00a0waiting period unnecessary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15568","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T04:59:07Z","timestamp":1653973147000},"page":"1725-1733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Assessment of the need of a waiting period after pulmonary vein isolation with the ablation index software"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9791-767X","authenticated-orcid":false,"given":"Pedro A.","family":"Sousa","sequence":"first","affiliation":[{"name":"Pacing and Electrophysiology Unit, Cardiology Department Coimbra's Hospital and University Center Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4064-3767","authenticated-orcid":false,"given":"S\u00e9rgio","family":"Barra","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital da Luz Arr\u00e1bida V. N. Gaia Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds","family":"Ad\u00e3o","sequence":"additional","affiliation":[{"name":"Cardiology Department University Hospital Center of S\u00e3o Jo\u00e3o Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Primo","sequence":"additional","affiliation":[{"name":"Cardiology Department Vila Nova de Gaia and Espinho Hospital Center V. N. Gaia Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad","family":"Khoueiry","sequence":"additional","affiliation":[{"name":"Cardiology Department Clinique Saint Pierre Perpignan France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6173-3449","authenticated-orcid":false,"given":"Lu\u00eds","family":"Puga","sequence":"additional","affiliation":[{"name":"Pacing and Electrophysiology Unit, Cardiology Department Coimbra's Hospital and University Center Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7827-4042","authenticated-orcid":false,"given":"Ana","family":"Lebreiro","sequence":"additional","affiliation":[{"name":"Cardiology Department University Hospital Center of S\u00e3o Jo\u00e3o Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Cardiology Department Vila Nova de Gaia and Espinho Hospital Center V. N. Gaia Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lagrange","sequence":"additional","affiliation":[{"name":"Cardiology Department Clinique Saint Pierre Perpignan France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lino","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Pacing and Electrophysiology Unit, Cardiology Department Coimbra's Hospital and University Center Coimbra Portugal"},{"name":"ICBR, Faculty of Medicine University of Coimbra Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Study Group Members","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000151289.73085.36"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.05.012"},{"issue":"5","key":"e_1_2_10_5_1","first-page":"S114","article-title":"Ablation index predicts sites of acute reconnection after pulmonary vein isolation: a multi\u2010center retrospective analysis","volume":"12","author":"Das M","year":"2015","journal-title":"Heart Rhythm"},{"key":"e_1_2_10_6_1","first-page":"775","article-title":"Ablation index, a novel marker of ablation lesion quality: prediction of pulmonary vein reconnection at repeat electrophysiology study and regional differences in target values","volume":"19","author":"Das M","year":"2017","journal-title":"Europace"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13281"},{"key":"e_1_2_10_8_1","first-page":"99","article-title":"Evaluation of a strategy aiming to enclose the pulmonary veins with contiguous and optimized radiofrequency lesions in paroxysmal atrial fibrillation","volume":"4","author":"Taghji P","year":"2018","journal-title":"J Am Coll Cardiol EP"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.962720"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13710"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-019-00565-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.118.006576"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaa157"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60026-5"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.07.033"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eum101"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12933"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.110.960138"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu329"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv057"},{"issue":"481","key":"e_1_2_10_21_1","first-page":"1085","article-title":"Prospective study to test the ability to create RF lesions at predicted depths of 3, 5, 7 and 9 mm using a new formula incorporating contact force, radiofrequency power and application time (force\u2010power\u2010time index) in the beating canine heart","volume":"10","author":"Nakagawa H","year":"2013","journal-title":"Heart Rhythm"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus048"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12396"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.11.017"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.120.008316"},{"key":"e_1_2_10_26_1","doi-asserted-by":"crossref","unstructured":"KaticJ AnicA BreskovicT JurisicZ.Higher than recommended lesion size index target values for pulmonary vein isolation result in better clinical outcomes in paroxysmal atrial fibrillation patients.J Interv Card Electrophysiol.2021.doi:10.1007\/s10840-021-01053-4","DOI":"10.1007\/s10840-021-01053-4"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15041"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15152"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.10.016"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15568","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.15568","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T11:22:26Z","timestamp":1692789746000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.15568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,14]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/jce.15568"],"URL":"https:\/\/doi.org\/10.1111\/jce.15568","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,14]]},"assertion":[{"value":"2022-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}