{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T22:00:11Z","timestamp":1773698411265,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fever is a potential side effect of the Covid\u201019 vaccination. Patients with Brugada syndrome (BrS) have an increased risk of life\u2010threatening arrhythmias when experiencing fever. Prompt treatment with antipyretic drugs is suggested in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim of the study<\/jats:title><jats:p>To evaluate the incidence and management of fever within 48\u2009h from Covid\u201019 vaccination among BrS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred sixty\u2010three consecutive patients were enrolled in a prospective registry involving five European hospitals with a dedicated inherited disease ambulatory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 50\u2009\u00b1\u200914 years and 121 (75%) patients were male. Prevalence of Brugada electrocardiogram\u00a0(ECG) pattern type\u20101, \u20102, and \u20103 was 32%, 44%, and 24%, respectively. Twenty\u2010eight (17%) patients had an implantable cardioverter\u2010defibrillator (ICD). Fever occurred in 32 (19%) BrS patients after 16\u2009\u00b1\u200910\u2009h from vaccination, with a peak of body temperature of 37.9\u00b0\u2009\u00b1\u20090.5\u00b0. Patients with fever were younger (39\u2009\u00b1\u200913 vs. 48\u2009\u00b1\u200913 years, <jats:italic>p<\/jats:italic>\u2009=\u2009.04). No additional differences in terms of sex and cardiovascular risk factors were found between patients with fever and not.\u00a0Twenty\u2010seven (84%) out of 32 patients experienced mild fever and five (16%) moderate fever. Pharmacological treatment with antipyretic drugs was required in 18 (56%) out of 32 patients and was associated with the resolution of symptoms. No patient required hospital admission and no arrhythmic episode was recorded in patients with ICD within 48\u2009h after vaccination. No induced type 1 BrS ECG pattern and new ECG features were found among patients with moderate fever.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fever is a common side effect in BrS patients after the Covid\u201019 vaccination. Careful evaluation of body temperature and prompt treatment with antipyretic drugs may be needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15596","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T14:22:23Z","timestamp":1655130143000},"page":"1874-1879","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Fever following Covid\u201019 vaccination in subjects with Brugada syndrome: Incidence and management"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9909-6513","authenticated-orcid":false,"given":"Francesco","family":"Santoro","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Foggia  Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Crea","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Clinical and Experimental Medicine University of Messina, Policlinico G. Martino  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2961-2783","authenticated-orcid":false,"given":"Pier Luigi","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Policlinico Riuniti University Hospital Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Cetera","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Foggia  Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Gianfrancesco","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bonomo Hospital, ASL BAT  Andria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4766-5523","authenticated-orcid":false,"given":"Mohammad","family":"Abumayyaleh","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Mannheim  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dattilo","family":"Giuseppe","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Clinical and Experimental Medicine University of Messina, Policlinico G. Martino  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Allegra","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Clinical and Experimental Medicine University of Messina, Policlinico G. Martino  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nastasia","family":"Mancini","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Clinical and Experimental Medicine University of Messina, Policlinico G. Martino  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girolamo","family":"D'Arienzo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Policlinico Riuniti University Hospital Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"M\u0215gge","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology Bergmannsheil University Hospitals, Ruhr University of Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assem","family":"Aweimer","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology Bergmannsheil University Hospitals, Ruhr University of Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Bartolomucci","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bonomo Hospital, ASL BAT  Andria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Akin","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Mannheim  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"El\u2010Battrawy","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Mannheim  Mannheim Germany"},{"name":"Department of Cardiology and Angiology Bergmannsheil University Hospitals, Ruhr University of Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9610-7408","authenticated-orcid":false,"given":"Natale Daniele","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Foggia  Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx490"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2015.06.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.118.002263"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euz122"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00261"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030692"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000034169.45752.4A"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.04.007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab070"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00224-3"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2011.05.002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.07.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12723"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166143"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.07.030"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.03.044"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.08.862"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-3-200808050-00020"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.05.014"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2035389"},{"key":"e_1_2_8_23_1","first-page":"NEJMoa2105290","article-title":"Phase 3 safety and efficacy of AZD1222 (ChAdOx1 nCoV\u201019) Covid\u201019 vaccine","volume":"29","author":"Falsey AR","year":"2021","journal-title":"N Engl J Med"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2101544"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-21-0750"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15596","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.15596","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T11:21:43Z","timestamp":1692789703000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.15596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,21]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/jce.15596"],"URL":"https:\/\/doi.org\/10.1111\/jce.15596","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,21]]},"assertion":[{"value":"2022-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}