{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:43:45Z","timestamp":1790959425147,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Premature\u2010ventricular\u2010complexes (template\/fixation beat) guided left bundle branch pacing (LBBP) was recently described as a novel method of successful lead deployment by rapid rotations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We aimed at analyzing the incidence of a unique morphology template beat, which we labelled as \u2018M\u2010beat\u2019 in patients undergoing PVC\u2010guided LBBP, its ability to predict selective LBB\u2010capture and clinical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall 210 out of 217 attempted\u2010patients (96.7%) underwent successful LBBP. Template beat was noted in 90.4% patients (<jats:italic>n<\/jats:italic>\u2009=\u2009190) and M\u2010beat in 32.8%(<jats:italic>n<\/jats:italic>\u2009=\u200969). Non\u2010selective to selective capture transition demonstrated in 55.2%(<jats:italic>n<\/jats:italic>\u2009=\u2009116). The QRS duration of the M\u2010beat was 129.3\u2009\u00b1\u200913.1ms. Patients were divided into two groups: Group\u2010I with M\u2010beat (<jats:italic>n<\/jats:italic>\u2009=\u200969;32.8%) and Group\u2010II without M\u2010beat (<jats:italic>n<\/jats:italic>\u2009=\u2009141; 67.2%). The mean fluoroscopy\u2010time was significantly less in group\u2010I as compared to group\u2010II (13.1\u2009\u00b1\u200911.1 vs 16.8\u2009\u00b1\u200912.04 minutes; p\u20120.03). Patients in group\u2010II required more attempts as compared to group\u2010I for successful lead deployment (2.8\u2009\u00b1\u20091.09 vs 2.2\u2009\u00b1\u20091.04; p \u2012 0.01). Six patients showed loss of R\u2010wave in lead\u2010V1 and 2 showed rise in LBB capture threshold by &gt;1V during follow\u2010up in group\u2010II. M\u2010beat had a specificity of 96.77% and sensitivity of 58.62% (positive\u2010predictive\u2010value\u201098.55%) to predict selective\u2010LBB capture. Myocardial excitability would not modify the occurrence of M\u2010beat as opposed to capture transition response since it could be demonstrated without pacing protocols. When confirmation of LBB\u2010capture itself would be difficult in patients with baseline LBBB\u2010morphology, M\u2010beat with 42.8% incidence predicted selective capture with 96.7% specificity and 66.04% sensitivity(positive\u2010predictive\u2010value\u201097.22%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>M\u2010beat is a marker of transient\u2010selective LBB\u2010capture, independent of the local myocardial excitability with high specificity and positive predictive value irrespective of the baseline QRS morphology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15597","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T14:22:39Z","timestamp":1655130159000},"page":"1888-1892","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["M\u2010beat\u2014A novel marker for selective left bundle branch capture"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7059-425X","authenticated-orcid":false,"given":"Shunmuga Sundaram","family":"Ponnusamy","sequence":"first","affiliation":[{"name":"Department of Cardiology Velammal Medical College Madurai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Basil","sequence":"additional","affiliation":[{"name":"Medtronic India Private Limited Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2230-100X","authenticated-orcid":false,"given":"Pugazhendhi","family":"Vijayaraman","sequence":"additional","affiliation":[{"name":"Department of Medicine Geisinger Heart Institute Geisinger Commonwealth School of Medicine Wilkes Barre Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14681"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrcr.2020.08.010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.120.009677"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2020.12.019"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.05.011"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.120.009261"},{"issue":"9","key":"e_1_2_6_8_1","first-page":"1166","article-title":"Evaluation of the criteria to distinguish left bundle branch pacing from left ventricular septal pacing","volume":"7","author":"Wu S","year":"2021","journal-title":"J Am Coll Cardiol EP"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.06.016"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2021.07.001"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14352"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15597","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.15597","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T11:21:46Z","timestamp":1692789706000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.15597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,21]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/jce.15597"],"URL":"https:\/\/doi.org\/10.1111\/jce.15597","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,21]]},"assertion":[{"value":"2022-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}