{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:20:52Z","timestamp":1790443252141,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T00:00:00Z","timestamp":1657929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We assessed the prevalence of non\u2010type 1 Brugada pattern (T1BrP) in children and young adults from the Sudden Cardiac Death\u2010Screening Of risk factorS cohort and the diagnostic yield of nonexpert manual and automatic algorithm electrocardiogram (ECG) measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional study. We reviewed 14\u2009662 ECGs and identified 2226 with a rSr\u2032\u2010pattern in V1\u2010V2. Among these, 115 were classified by experts in hereditary arrhythmic\u2010syndromes as having or not non\u2010T1BrP, and were compared with measurements of 5 ECG\u2010derived parameters based on a triangle formed by r\u2032 \u2010wave (d(A), d(B), d(B)\/h, \u03b2\u2010angle) and ST\u2010ascent, assessed both automatically and manually by nonexperts. We estimated intra\u2010 and interobserver concordance for each criterion, calculated diagnostic accuracy and defined the most appropriate cut\u2010off values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A rSr\u2032\u2010pattern in V1\u2010V2 was associated with higher PQ interval and QRS duration, male gender, and lower body mass index (BMI). The manual measurements of non\u2010T1BrP criteria were moderately reproducible with high intraobserver and moderate interobserver concordance coefficients (ICC: 0.72\u20130.98, and 0.63\u20130.76). Criteria with higher discriminatory capacity were: distance d(B) (0.72; 95% confidence interval [CI]: 0.65\u22120.80) and ST\u2010ascent (0.87; 95% CI: 0.82\u20130.92), which was superior to the 4 r\u2032\u2010wave criteria together (area under curve [AUC: 0.74]). We suggest new cut\u2010offs with improved combination of sensitivity and specificity: d(B)\u2009\u2265\u20091.4\u2009mm and ST\u2010ascent\u2009\u2265\u20090.7\u2009mm (sensitivity: 1%\u201382%; specificity: 71%\u201384%), that can be automatically measured to allow classification in four morphologies with increasing non\u2010T1BrP probability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>rSr\u2032\u2010pattern in precordial leads V1\u2010V2 is a frequent finding and the detection of non\u2010T1BrP by using the aforementioned five measurements is reproducible and accurate. In this study, we describe new cut\u2010off values that may help untrained clinicians to identify young individuals who may require further work\u2010up for a potential Brugada Syndrome diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15615","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T15:12:50Z","timestamp":1656601970000},"page":"2083-2091","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Defining electrocardiographic criteria to differentiate non\u2010type 1 Brugada ECG variants from normal incomplete RBBB patterns in the young SCD\u2010SOS cohort"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4491-5312","authenticated-orcid":false,"given":"Mafalda","family":"Carrington","sequence":"first","affiliation":[{"name":"Cardiology Department Hospital do Esp\u00edrito Santo de \u00c9vora  \u00c9vora Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7743-0143","authenticated-orcid":false,"given":"Antonio","family":"Creta","sequence":"additional","affiliation":[{"name":"Cardiology Department Barts Heart Centre, Barts Health NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9831-6817","authenticated-orcid":false,"given":"William J.","family":"Young","sequence":"additional","affiliation":[{"name":"Cardiology Department Barts Heart Centre, Barts Health NHS Trust  London UK"},{"name":"William Harvey Research Institute Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Carrington","sequence":"additional","affiliation":[{"name":"IE Business School Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Henriques","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Centro de Inform\u00e1tica e Sistemas Universidade de Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4998-2247","authenticated-orcid":false,"given":"Rog\u00e9rio","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Cardiology Department Centro Hospitalar Universit\u00e1rio de Coimbra  Coimbra Portugal"},{"name":"Faculdade de Medicina Universidade de Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9255-3064","authenticated-orcid":false,"given":"Lino","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Cardiology Department Centro Hospitalar Universit\u00e1rio de Coimbra  Coimbra Portugal"},{"name":"Faculdade de Medicina Universidade de Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9055-9267","authenticated-orcid":false,"given":"Pier D.","family":"Lambiase","sequence":"additional","affiliation":[{"name":"Cardiology Department Barts Heart Centre, Barts Health NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9141-9883","authenticated-orcid":false,"given":"Rui","family":"Provid\u00eancia","sequence":"additional","affiliation":[{"name":"Cardiology Department Barts Heart Centre, Barts Health NHS Trust  London UK"},{"name":"Institute of Health Informatics Research University College London  London 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