{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T02:09:41Z","timestamp":1762999781196,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This prospective trial sought to phenotype persistent atrial fibrillation (AF) based on AF mechanisms using electrocardiographic imaging\u00a0(ECGI) mapping to determine whether this would predict long\u2010term freedom from arrhythmia after pulmonary vein isolation (PVI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with persistent AF of &lt;2 years duration underwent cryoballoon PVI. ECGI mapping was performed before PVI\u00a0to determine potential drivers (PDs) defined as rotational activations completing \u22651.5 revolutions or focal activations. The coprimary endpoint was the association between (1) PD burden (defined as the number of PD occurrences) and (2) PD distribution (defined as the number of segments on an 18\u2010segment model of the atria harboring PDs) with freedom from arrhythmia at 1\u2010year follow up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 100 patients, 97 completed follow up and 52 (53.6%) remained in sinus rhythm off antiarrhythmic drugs. Neither PD burden nor PD distribution predicted freedom from arrhythmia (hazard ratio [HR]: 1.01, 95% confidence interval [CI]: 0.99\u20131.03, <jats:italic>p<\/jats:italic>\u2009=\u2009.164; and HR: 1.04, 95% CI: 0.91\u20131.17, <jats:italic>p<\/jats:italic>\u2009=\u2009.591, respectively). Otherwise, the burden of rotational PDs, rotational stability, and the burden of PDs occurring at the pulmonary veins and posterior wall all failed to predict arrhythmia recurrence (all <jats:italic>p<\/jats:italic>\u2009&gt;\u2009.10).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AF mechanisms as determined using ECGI mapping do not predict outcomes after PVI for persistent AF. Further studies using different methodologies to characterize AF mechanisms are warranted\u00a0(NCT03394404).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15644","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T08:28:09Z","timestamp":1659601689000},"page":"2263-2273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["ECG\u2010I phenotyping of persistent AF based on driver burden and distribution to predict response to pulmonary vein isolation (PHENOTYPE\u2010AF)"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1197-9328","authenticated-orcid":false,"given":"Gurpreet S.","family":"Dhillon","sequence":"first","affiliation":[{"name":"Department of Electrophysiology, Barts Heart Centre, St Bartholomew's Hospital Barts Health NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0081-5739","authenticated-orcid":false,"given":"Shohreh","family":"Honarbakhsh","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Barts Heart Centre, St Bartholomew's Hospital Barts Health NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Barts Heart Centre, St Bartholomew's Hospital Barts Health NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakam","family":"Abbass","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Barts Heart Centre, St Bartholomew's Hospital Barts Health NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Welch","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Barts Heart Centre, St Bartholomew's Hospital Barts Health NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly","family":"Daw","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Barts Heart Centre, St Bartholomew's Hospital Barts Health NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Sporton","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Barts Heart Centre, St Bartholomew's Hospital Barts Health NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9141-9883","authenticated-orcid":false,"given":"Rui","family":"Providencia","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Barts Heart Centre, St Bartholomew's Hospital Barts Health NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Barts Heart Centre, St Bartholomew's Hospital Barts Health NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Earley","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Barts Heart Centre, St Bartholomew's Hospital Barts Health NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Lowe","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Barts Heart Centre, St Bartholomew's Hospital Barts Health NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier D.","family":"Lambiase","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Barts Heart Centre, St Bartholomew's Hospital Barts Health NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Schilling","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Barts Heart Centre, St Bartholomew's Hospital Barts Health NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross J.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Barts Heart Centre, St Bartholomew's Hospital Barts Health NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.109.859116"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux297"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408288"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.09.088"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccep.2014.11.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2019.04.007"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.09.177"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14392"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.01.014"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw168"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2022.01.042"},{"key":"e_1_2_9_13_1","first-page":"008824","article-title":"Prospective STAR guided ablation in persistent AF using sequential mapping with multipolar catheters","volume":"13","author":"Honarbakhsh S","year":"2020","journal-title":"Circulation"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408288"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13437"},{"issue":"20","key":"e_1_2_9_16_1","first-page":"157","article-title":"HRS\/EHRA\/ECAS\/APHRS\/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary","volume":"2018","author":"Calkins H","year":"2017","journal-title":"Europace Elsevier Inc"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euz313"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.10.038"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2020.04.020"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux295"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-015-0856-x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.07.018"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.05.022"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005421"},{"key":"e_1_2_9_26_1","first-page":"622","article-title":"Characterization of fractionated atrial electrograms critical for maintenance of atrial fibrillation a randomized, controlled trial of ablation strategies (the CFAE AF trial)","volume":"4","author":"Hunter RJ","year":"2011","journal-title":"Circulation"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.10.046"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13752"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13742"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-015-0616-6"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15644","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.15644","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T08:38:48Z","timestamp":1692607128000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.15644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,16]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/jce.15644"],"URL":"https:\/\/doi.org\/10.1111\/jce.15644","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"type":"print","value":"1045-3873"},{"type":"electronic","value":"1540-8167"}],"subject":[],"published":{"date-parts":[[2022,8,16]]},"assertion":[{"value":"2022-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}