{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:29:27Z","timestamp":1788542967272,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Micra atrioventricular\u00a0(AV) provides leadless atrioventricular synchronous pacing by sensing atrial contraction (A4 signal). Real\u2010world operation and reliability of AV synchrony (AVS) assessment using device data have not been described. The purposes of this study were to (1) assess the correlation between AVS and atrial mechanical sensed\u2010ventricular pacing\u00a0(AM\u2010VP) percentages in patients with permanent high\u2010degree AV block and (2) report on the real\u2010world effectiveness of Micra AV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The correlation between ECG\u2010determined AVS in\u2010clinic and device\u2010collected %AM\u2010VP was assessed using data from 40 patients with high\u2010degree AV block enrolled in the Micra Atrial tRacking using a Ventricular AccELerometer\u00a0(MARVEL) 2 study. A retrospective analysis to assess continuously\u2010sampled %AM\u2010VP since last session, device programming, and electrical parameters was performed using Micra AV transmissions from the Medtronic CareLink database. Patients with transmissions \u2265180 days postimplant were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 40 MARVEL 2 AV block patients with a median %VP of 99.7%, AVS was highly correlated with AM\u2010VP (median AVS 87.1%, median AM\u2010VP 79.1%; <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.764, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The CareLink cohort included 4384 patients programmed to VDD mode. The mean A4 amplitude was 2.3\u2009\u00b1\u20091.8\u2009m\/s<jats:sup>2<\/jats:sup> at implant and 2.3\u2009\u00b1\u20091.6\u2009m\/s<jats:sup>2<\/jats:sup> at 28 weeks. In patients with %VP\u00a0&gt;90% (<jats:italic>n<\/jats:italic>\u2009=\u20091662), the median %AM\u2010VP was 74.7%. For the full cohort, median %VP was 65.6% and median projected battery longevity was 10.5 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with a high pacing burden, %AM\u2010VP provides a reasonable estimation of AVS. The first large real\u2010world analysis of Micra AV patients with &gt;90% VP showed stable atrial sensing over time with a median %AM\u2010VP, a correlate of AVS, of 74.7%.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15726","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T08:06:43Z","timestamp":1667290003000},"page":"197-206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Correlation between AV synchrony and device collected AM\u2010VP sequence counter in atrioventricular synchronous leadless pacemakers: A real\u2010world assessment"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2173-1035","authenticated-orcid":false,"given":"Christophe","family":"Garweg","sequence":"first","affiliation":[{"name":"University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0772-2404","authenticated-orcid":false,"given":"Jonathan P.","family":"Piccini","sequence":"additional","affiliation":[{"name":"Duke University Medical Center and Duke Clinical Research Institute Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence M.","family":"Epstein","sequence":"additional","affiliation":[{"name":"Department of Cardiology Northwell Health Manhasset New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Frazier\u2010Mills","sequence":"additional","affiliation":[{"name":"Duke University Medical Center and Duke Clinical Research Institute Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4454-6761","authenticated-orcid":false,"given":"Larry A.","family":"Chinitz","sequence":"additional","affiliation":[{"name":"NYU Langone Medical Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Steinwender","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kepler University Hospital Linz Linz Austria"},{"name":"Department of Cardiology Paracelsus Medical University Salzburg Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Stromberg","sequence":"additional","affiliation":[{"name":"Medtronic, Inc. Mounds View Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Sheldon","sequence":"additional","affiliation":[{"name":"Medtronic, Inc. Mounds View Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1430-4588","authenticated-orcid":false,"given":"Dedra H.","family":"Fagan","sequence":"additional","affiliation":[{"name":"Medtronic, Inc. Mounds View Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4978-7177","authenticated-orcid":false,"given":"Mikhael F.","family":"El\u2010Chami","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511643"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.08.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab364"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2019.10.017"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hroo.2021.08.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2019.10.017"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.11.086"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1996.tb06516.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2003.00352.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02310-X"},{"issue":"8","key":"e_1_2_9_12_1","first-page":"382","article-title":"2018 ACC\/AHA\/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: a report of the American College of Cardiology\/American Heart Association Task Force on clinical practice guidelines and the Heart Rhythm Society","volume":"140","author":"Kusumoto FM","year":"2019","journal-title":"Circulation"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2021.12.025"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15726","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.15726","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T12:16:47Z","timestamp":1692447407000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.15726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,15]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/jce.15726"],"URL":"https:\/\/doi.org\/10.1111\/jce.15726","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,15]]},"assertion":[{"value":"2022-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}