{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:10:42Z","timestamp":1770833442182,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T00:00:00Z","timestamp":1668902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Scar\u2010related ventricular tachycardia (VT) usually results from an underlying reentrant circuit facilitated by anatomical and functional barriers. The later are sensitive to the direction of ventricular activation wavefronts. We aim to evaluate the impact of different ventricular activation wavefronts on the functional electrophysiological properties of myocardial tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with ischemic heart disease referred for VT ablation underwent high\u2010density mapping using Carto\u00ae3 (Biosense Webster). Maps were generated during sinus rhythm, right and left ventricular pacing, and analyzed using a new late potential map software, which allows to assess local conduction velocities\u00a0and facilitates the delineation of intra\u2010scar conduction corridors (ISCC); and for all stable VTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 16 patients, 31 high\u2010resolution substrate maps from different ventricular activation wavefronts and 7 VT activation maps were obtained. Local abnormal ventricular activities (LAVAs) were found in VT isthmus, but also in noncritical areas. The VT isthmus was localized in areas of LAVAs overlapping surface between the different activation wavefronts. The deceleration zone location differed depending on activation wavefronts. Sixty\u2010six percent of ISCCs were similarly identified in all activating wavefronts, but the one acting as VT isthmus was simultaneously identified in all activation wavefronts in all cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Functional based substrate mapping may improve the specificity to localize the most arrhythmogenic regions within the scar, making the use of different activation wavefronts unnecessary in most cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15740","type":"journal-article","created":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T20:20:30Z","timestamp":1667766030000},"page":"389-399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of different activation wavefronts on ischemic myocardial scar electrophysiological properties during high\u2010density ventricular tachycardia mapping and ablation"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3138-8354","authenticated-orcid":false,"given":"Gustavo","family":"Lima da Silva","sequence":"first","affiliation":[{"name":"Cardiology Department, Santa Maria University Hospital (CHULN) Lisbon Academic Medical Centre Lisbon Portugal"},{"name":"Cardiac Rhythm Abnormalities Unit, Cardiovascular Centre of the University of Lisbon Lisbon School of Medicine of the Universidade de Lisboa Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9244-4631","authenticated-orcid":false,"given":"Nuno","family":"Cortez\u2010Dias","sequence":"additional","affiliation":[{"name":"Cardiology Department, Santa Maria University Hospital (CHULN) Lisbon Academic Medical Centre Lisbon Portugal"},{"name":"Cardiac Rhythm Abnormalities Unit, Cardiovascular Centre of the University of Lisbon Lisbon School of Medicine of the Universidade de Lisboa Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2836-9497","authenticated-orcid":false,"given":"Afonso","family":"Nunes Ferreira","sequence":"additional","affiliation":[{"name":"Cardiology Department, Santa Maria University Hospital (CHULN) Lisbon Academic Medical Centre Lisbon Portugal"},{"name":"Cardiac Rhythm Abnormalities Unit, Cardiovascular Centre of the University of Lisbon Lisbon School of Medicine of the Universidade de Lisboa Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elad","family":"Nakar","sequence":"additional","affiliation":[{"name":"Research and Development Department, Biosense Webster Johnson &amp; Johnson Yokneam Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Francisco","sequence":"additional","affiliation":[{"name":"Biosense Webster, Johnson &amp; Johnson EMEA Clinical Development Diegem Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Pereira","sequence":"additional","affiliation":[{"name":"Biosense Webster, Johnson &amp; Johnson Clinical Support Porto Salvo Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Moreno","sequence":"additional","affiliation":[{"name":"Cardiology Department, Arrhythmia Unit University Hospital Ram\u00f3n y Cajal and CIBER\u2010CV Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5716-6712","authenticated-orcid":false,"given":"Rapha\u00ebl P.","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rennes University Hospital Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fausto J.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Cardiology Department, Santa Maria University Hospital (CHULN) Lisbon Academic Medical Centre Lisbon Portugal"},{"name":"Cardiac Rhythm Abnormalities Unit, Cardiovascular Centre of the University of Lisbon Lisbon School of Medicine of the Universidade de Lisboa Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Cardiology Department, Santa Maria University Hospital (CHULN) Lisbon Academic Medical Centre Lisbon Portugal"},{"name":"Cardiac Rhythm Abnormalities Unit, Cardiovascular Centre of the University of Lisbon Lisbon School of Medicine of the Universidade de Lisboa Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.118.006569"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.12.044"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.050363"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.043216"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.026"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.117.005635"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux109"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.08.031"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2018.04.007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2015.09.001"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02623-2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15470"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2009.01462.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2018.07.012"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.116.004155"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.115.003841"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12761"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.119.007293"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.042423"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.120.008625"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.12.005"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15740","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.15740","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T14:14:09Z","timestamp":1692540849000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.15740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,20]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/jce.15740"],"URL":"https:\/\/doi.org\/10.1111\/jce.15740","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,20]]},"assertion":[{"value":"2022-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}