{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:26:22Z","timestamp":1740137182515,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T00:00:00Z","timestamp":1668902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Brugada syndrome (BrS), which is characterized by J\u2010point elevation in right precordial leads of a 12\u2010lead electrocardiogram, is associated with the occurrence of ventricular fibrillation (VF). However, risk stratification of VF in patients with BrS remains challenging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to identify a risk predictor of VF in patients with BrS using pharmacological tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010one consecutive patients with BrS and a history of documented spontaneous VF (<jats:italic>n<\/jats:italic>\u2009=\u200916) or syncope presumed to be caused by lethal ventricular arrhythmia (<jats:italic>n<\/jats:italic>\u2009=\u20095) were enrolled. J\u2010wave changes in response to intravenous verapamil, propranolol, and pilsicainide were separately assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the median follow\u2010up period of 86.0 months, 8 patients had VF recurrence (recurrence group) and 13 patients did not have VF recurrence (non\u2010recurrence group). Intravenous propranolol injection induced significant J\u2010wave augmentation (i.e., increase in amplitude &gt;0.1\u2009mV) in the inferior and\/or lateral leads in the recurrence group compared to the non\u2010recurrence group (<jats:italic>p<\/jats:italic>\u2009=\u2009.048 and <jats:italic>p<\/jats:italic>\u2009=\u2009.015, respectively). Kaplan\u2013Meier analysis revealed that VF recurrence is significantly higher in patients with BrS and J\u2010wave augmentation due to intravenous propranolol than in patients without J\u2010wave augmentation (<jats:italic>p<\/jats:italic>\u2009=\u2009.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study results show that propranolol\u2010induced J\u2010wave augmentation is involved in the risk of VF in patients with BrS. The results suggest that early repolarization patterns in response to pharmacological tests may be useful for risk stratification of VF in patients with symptomatic BrS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15746","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T06:24:07Z","timestamp":1668061447000},"page":"180-188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk stratification of ventricular fibrillation in patients with symptomatic Brugada syndrome using pharmacological tests"],"prefix":"10.1111","volume":"34","author":[{"given":"Kyoko","family":"Kawano","sequence":"first","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine Oita University Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuji","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Department of Cardiology and 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