{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:26:23Z","timestamp":1740137183376,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Defibrillation testing (DFT) is recommended during subcutaneous implantable cardioverter\u2010defibrillator (S\u2010ICD) implantation. Previous studies analyzing the potential interference of propofol with defibrillation threshold are inconsistent. The purpose of this study was to analyze whether propofol affects DFT post S\u2010ICD placement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients with S\u2010ICD implantation between 01\/2017 and 11\/2020 at the University Heart Center Freiburg were retrospectively analyzed. Two groups were generated depending on the success of the first shock during DFT. Implantation characteristics and dose of anesthetics were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 12 of the included 80 (15%) patients, first shock during DFT failed. The absolute dose of propofol was significantly higher in patients with first shock failure (median 653\u2009mg [IQR 503\u2013855]) compared to patients with first shock termination (376\u2009mg [200\u2013600]; <jats:italic>p<\/jats:italic>\u2009=\u20090.027). Doses of opioids and midazolam as well as type of anesthesia did not differ between the groups. A multivariable binary logistic regression analysis confirmed an independent association of first shock termination and propofol dose (per 100\u2009mg: OR 0.73 (95% CI: 0.56\u20130.95); <jats:italic>p<\/jats:italic>\u2009=\u20090.021).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is an independent association of propofol dose and first shock failure in routine\u00a0S\u2010ICD defibrillation testing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15762","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T10:48:50Z","timestamp":1669718930000},"page":"420-428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Propofol dose and efficacy of defibrillation testing during implantation of subcutaneous implantable cardioverter\u2010defibrillators: A\u00a0retrospective, single center cohort study"],"prefix":"10.1111","volume":"34","author":[{"given":"Luca","family":"Trolese","sequence":"first","affiliation":[{"name":"Department of Cardiology and Angiology, Faculty of Medicine, Heart Center Freiburg University University of Freiburg Freiburg Germany"},{"name":"Department of Rhythmology Ortenau Klinikum Offenburg\u2010Lahr Lahr Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5572-2620","authenticated-orcid":false,"given":"Pietro Bernardo","family":"Dall'Aglio","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, Faculty of Medicine, Heart Center Freiburg University University of Freiburg Freiburg Germany"},{"name":"Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Steinfurt","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, Faculty of Medicine, Heart Center Freiburg University University of Freiburg Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Gressler","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, Faculty of Medicine, Heart Center Freiburg University University of Freiburg Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, Faculty of Medicine, Heart Center Freiburg University University of Freiburg Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Cipriani","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padova Padova 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