{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:22:03Z","timestamp":1777656123198,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Idiopathic ventricular fibrillation (IVF) is mainly associated with and triggered by short\u2010coupled (R\u2010on\u2010T) ventricular ectopics. However, little is known about the risk of VF associated with long\u2010coupled premature ventricular complexes (LCPVCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the prevalence and characteristics of IVF patients presenting with LCPVCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with IVF and PVCs from five\u00a0arrhythmia referral centers were reviewed. We included patients presenting LCPVCs, defined as PVCs falling after the end of the T wave, with a normal QTc interval. We evaluated demographics, medical history, and clinical circumstances associated with PVCs and VF episodes. The origin of PVCs was determined by invasive mapping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010nine patients with IVF were reviewed. Among them, 12 (15.2%) met the inclusion criteria (8 women, age 36\u2009\u00b1\u200914 years). Eleven patients had documented LCPVCs initiating repetitive PVCs or sustained VF, whereas 1\u00a0had only documented isolated PVCs. In 10 of 12 patients, PVCs were recorded showing both long and short coupling intervals of 418\u2009\u00b1\u200946\u00a0and 304\u2009\u00b1\u200933\u2009ms, respectively. Mapping showed that PVCs originated from the left Purkinje in 10 patients, from the right Purkinje in 1 patient, and both in 1 patient. Compared to other patients from the initial cohort, IVF with LCPVCs was associated with a left\u2010sided origin of PVCs (92% in long\u2010coupled IVF vs. 46% of left Purkinje PVCs in short\u2010coupled IVF, <jats:italic>p<\/jats:italic>\u2009=\u2009.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Long\u2010coupled fascicular PVCs, traditionally recognized as benign, can be associated with IVF in a subset of patients. They can induce IVF by themselves or in association with short\u2010coupled PVCs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15833","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T12:25:48Z","timestamp":1675772748000},"page":"615-623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Idiopathic ventricular fibrillation associated with long\u2010coupled Purkinje ectopy"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0362-6351","authenticated-orcid":false,"given":"Elodie","family":"Surget","sequence":"first","affiliation":[{"name":"IHU Liryc, Electrophysiology and Heart Modeling Institute Foundation Bordeaux Universit\u00e9 Bordeaux France"},{"name":"Electrophysiology and Ablation Unit Bordeaux University Hospital (CHU) Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4367-1117","authenticated-orcid":false,"given":"Josselin","family":"Duchateau","sequence":"additional","affiliation":[{"name":"IHU Liryc, Electrophysiology and Heart Modeling Institute Foundation Bordeaux Universit\u00e9 Bordeaux France"},{"name":"Electrophysiology and Ablation Unit Bordeaux University Hospital (CHU) Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Marchant","sequence":"additional","affiliation":[{"name":"IHU Liryc, Electrophysiology and Heart Modeling Institute Foundation Bordeaux Universit\u00e9 Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4800-1841","authenticated-orcid":false,"given":"Philippe","family":"Maury","sequence":"additional","affiliation":[{"name":"Cardiology Department Rangueil University Hospital Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Walton","sequence":"additional","affiliation":[{"name":"IHU Liryc, Electrophysiology and Heart Modeling Institute Foundation Bordeaux Universit\u00e9 Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Lavergne","sequence":"additional","affiliation":[{"name":"Cardiology Department Rhythmology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estelle","family":"Gandjbakhch","sequence":"additional","affiliation":[{"name":"Institute of Cardiology Piti\u00e9\u2010Salp\u00eatri\u00e8re University Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Leenhardt","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9, CNMR, Maladies Cardiaques H\u00e9r\u00e9ditaires Rares APHP H\u00f4pital Bichat Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Extramiana","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9, CNMR, Maladies Cardiaques H\u00e9r\u00e9ditaires Rares APHP H\u00f4pital Bichat Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Ha\u00efssaguerre","sequence":"additional","affiliation":[{"name":"IHU Liryc, Electrophysiology and Heart Modeling Institute Foundation Bordeaux Universit\u00e9 Bordeaux France"},{"name":"Electrophysiology and Ablation Unit Bordeaux University Hospital (CHU) Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac262"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1949.tb09547.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1948.tb10076.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.1.206"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1997.tb00997.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2022.04.013"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.057878"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000027564.55739.B1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab275"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.193"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abi9317"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.020153"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu165"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2021.07.007"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.03.151"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.54.240"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2012.42.8.575"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.88.257"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.757"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrcr.2020.04.016"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrcr.2015.02.008"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2007.03.006"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.53.1147"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2007.00731.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccas.2021.01.018"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv134"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrcr.2017.03.004"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ipej.2017.05.006"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15833","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.15833","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T22:31:54Z","timestamp":1692570714000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.15833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,14]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/jce.15833"],"URL":"https:\/\/doi.org\/10.1111\/jce.15833","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,14]]},"assertion":[{"value":"2022-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}