{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:38:58Z","timestamp":1791337138292,"version":"4.3.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Thoracic impedance (TI) drops measured by implantable cardioverter\u2010defibrillators (ICDs) have been reported to correlate with ventricular tachycardia\/fibrillation (VT\/VF). The aim of our study was to assess the temporal association of decreasing TI trends with VT\/VF episodes through a longitudinal analysis of daily remote monitoring data from ICDs and cardiac resynchronization therapy defibrillators (CRT\u2010Ds).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Retrospective data from 2384 patients were randomized 1:1 into a derivation or validation cohort. The TI decrease rate was defined as the percentage of rolling weeks with a continuously decreasing TI trend. The derivation cohort was used to determine a TI decrease rate threshold for a \u226599% specificity of arrhythmia prediction. The associated risk of VT\/VF episodes was estimated in the validation cohort by dividing the available follow\u2010up into 60\u2010day assessment intervals. Analyses were performed separately for 1354 ICD and 1030 CRT\u2010D patients. During a median follow\u2010up of 2.0 years, 727 patients (30.4%) experienced 3298 confirmed VT\/VF episodes. In the ICD group, a TI decrease rate of &gt;60% was associated with a higher risk of VT\/VF episode in a 60\u2010day assessment interval (stratified hazard ratio, 1.42; 95% confidence interval (CI), 1.05\u20131.92; <jats:italic>p<\/jats:italic>\u2009=\u2009.023). The TI decrease preceded (40.8%) or followed (59.2%) the VT\/VF episodes. In the CRT\u2010D group, no association between TI decrease and VT\/VF episodes was observed (<jats:italic>p<\/jats:italic>\u2009=\u2009.84).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our longitudinal analysis, TI decrease was associated with VT\/VF episodes only in ICD patients. Preventive interventions may be difficult since episodes can occur before or after TI decrease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15834","type":"journal-article","created":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T16:59:57Z","timestamp":1675011597000},"page":"947-956","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Temporal association between drops in thoracic impedance and malignant ventricular arrhythmia: A longitudinal analysis of remote monitoring trends"],"prefix":"10.1111","volume":"34","author":[{"given":"Giovanna","family":"Rodio","sequence":"first","affiliation":[{"name":"Division of Cardiology Ospedale Santissima Annunziata Taranto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-1110","authenticated-orcid":false,"given":"Saverio","family":"Iacopino","sequence":"additional","affiliation":[{"name":"Villa Maria Care &amp; Research Cotignola (RA) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ennio C.","family":"Pisan\u00f2","sequence":"additional","affiliation":[{"name":"Ospedale Vito Fazzi Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Calvi","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero Universitaria Policlinico \"G.Rodolico \u2010 San Marco\" Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Rovaris","sequence":"additional","affiliation":[{"name":"Ospedale San Gerardo Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9388-3292","authenticated-orcid":false,"given":"Massimiliano","family":"Marini","sequence":"additional","affiliation":[{"name":"Ospedale Santa Chiara Trento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Giammaria","sequence":"additional","affiliation":[{"name":"Ospedali Martini e Maria Vittoria Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Caravati","sequence":"additional","affiliation":[{"name":"ASST dei sette laghi Ospedale di Circolo Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9518-5877","authenticated-orcid":false,"given":"Giampiero","family":"Maglia","sequence":"additional","affiliation":[{"name":"Ospedale Pugliese\u2010Ciaccio Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Zanotto","sequence":"additional","affiliation":[{"name":"Ospedale Mater Salutis Legnago Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8346-1387","authenticated-orcid":false,"given":"Paolo","family":"Della Bella","sequence":"additional","affiliation":[{"name":"IRCCS San Raffaele Scientific Institute Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4590-8584","authenticated-orcid":false,"given":"Mauro","family":"Biffi","sequence":"additional","affiliation":[{"name":"Policlinico Sant'Orsola\u2010Malpighi Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Curnis","sequence":"additional","affiliation":[{"name":"Spedali Civili Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2576-1653","authenticated-orcid":false,"given":"Massimiliano","family":"Maines","sequence":"additional","affiliation":[{"name":"Ospedale Santa Maria del Carmine Rovereto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Orsida","sequence":"additional","affiliation":[{"name":"Ospedale S. Antonio Abate Gallarate Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Santamaria","sequence":"additional","affiliation":[{"name":"Gemelli Molise Campobasso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9704-6715","authenticated-orcid":false,"given":"Giovanni","family":"Bisignani","sequence":"additional","affiliation":[{"name":"Ospedale Civile Ferrari Castrovillari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Baroni","sequence":"additional","affiliation":[{"name":"ASST Grande Ospedale Metropolitano Niguarda Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Lissoni","sequence":"additional","affiliation":[{"name":"Ospedale di Lodi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Duca","sequence":"additional","affiliation":[{"name":"IRCCS Neurolesi \u201cBonino\u2010Puleo\u201d Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni B.","family":"Forleo","sequence":"additional","affiliation":[{"name":"Ospedale Sacco Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Piemontese","sequence":"additional","affiliation":[{"name":"Azienda Socio Sanitaria Territoriale Lariana Como Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"De Salvia","sequence":"additional","affiliation":[{"name":"San Giovanni Bosco Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Miracapillo","sequence":"additional","affiliation":[{"name":"Ospedale della Misericordia Grosseto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Celentano","sequence":"additional","affiliation":[{"name":"Humanitas Gavazzeni Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Zecchin","sequence":"additional","affiliation":[{"name":"Ospedale di Cattinara Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Luzzi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Ospedale Santissima Annunziata Taranto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1584-7944","authenticated-orcid":false,"given":"Daniele","family":"Giacopelli","sequence":"additional","affiliation":[{"name":"Biotronik Italia S.P.A. Vimodrone Italy"},{"name":"University of Padova Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Gargaro","sequence":"additional","affiliation":[{"name":"Biotronik Italia S.P.A. Vimodrone Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"D'Onofrio","sequence":"additional","affiliation":[{"name":"Ospedale Monaldi Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.492207"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2007.03.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2019.01.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2010.01924.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13535"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2010.02746.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-021-10152-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23108"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-11-0327"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3909\/ricm0665"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.02.039"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.12.092"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2010.01947.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs121"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.057"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl099"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1608029"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac053"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2016.12.011"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euab170"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.9.2.7"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15834","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.15834","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:46:34Z","timestamp":1692578794000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.15834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,14]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/jce.15834"],"URL":"https:\/\/doi.org\/10.1111\/jce.15834","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,14]]},"assertion":[{"value":"2022-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}