{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:20:28Z","timestamp":1790727628365,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Left bundle branch area pacing (LBBAP) is achieved by advancing the lead tip deep in the septum. Most LBBAP implants are performed using the Medtronic SelectSecure\u2122 MRI SecureScan\u2122 Model 3830 featuring a unique 4 Fr fixed helix lumenless design. Details of lead use conditions and long\u2010term reliability have not been reported.\u00a0This\u00a0study\u00a0was\u00a0designed\u00a0to\u00a0quantify the mechanical use conditions for the 3830 lead during and after LBBAP implant, and to evaluate reliability using bench testing and simulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty bradycardia patients with implantation of the 3830 lead for LBBAP were enrolled. Use conditions of lead deployment at implantation were collected and computed tomography\u00a0(CT) scans were performed at 3\u2010month follow\u2010up. Curvature amplitude along the pacing lead was determined with CT images. Fatigue bending was performed using accelerated testing in a more severe environment than routine clinical use conditions. Conductor fracture rate in a simulated patient population was estimated based on clinical use conditions and fatigue test results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of attempts to place the 3830 lead for LBBAP was 2.1\u2009\u00b1\u20091.3 (range: 1\u20137) with 13\u2009\u00b1\u20096 lead rotations at the final attempt. Extreme implant conditions were simulated in bench testing with 5 applications of 20 turns followed by up to 400 million bending cycles. Reliability modeling predicted a 10\u2010year fracture rate of 0.02%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LBBAP implants require more lead rotations than standard pacing implants and result in unique lead bending. Application of simulated LBBAP use conditions to the 3830 lead in an accelerated in\u2010vitro model does not produce excess conductor fractures.<\/jats:p><jats:p>IMAGE\u2010LBBP Study ID of ClinicalTrial.GOV: NCT04119323.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15843","type":"journal-article","created":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T08:02:35Z","timestamp":1675497755000},"page":"718-725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Clinical use conditions of lead deployment and simulated lead fracture rate in left bundle branch area pacing"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5891-6589","authenticated-orcid":false,"given":"Jiangang","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keping","family":"Chen","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9224-6152","authenticated-orcid":false,"given":"Xingbin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanning","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Dai","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhao","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Himes","sequence":"additional","affiliation":[{"name":"Cardiac Rhythm Management Medtronic Plc.  Mounds View Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Lucas","sequence":"additional","affiliation":[{"name":"Cardiac Rhythm Management Medtronic Plc.  Mounds View Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wade","family":"Demmer","sequence":"additional","affiliation":[{"name":"Cardiac Rhythm Management Medtronic Plc.  Mounds View Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicki","family":"Mara","sequence":"additional","affiliation":[{"name":"Cardiac Rhythm Management Medtronic Plc.  Mounds View Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Cardiac Rhythm Management Medtronic Plc.  Mounds View Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4077-6802","authenticated-orcid":false,"given":"Hongyang","family":"Lu","sequence":"additional","affiliation":[{"name":"Cardiac Rhythm Management, Medtronic Technology Center Medtronic (Shanghai) Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.09.013"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euy252"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2020.07.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2020.07.026"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2021.08.033"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.120.009261"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2006.00452.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12995"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.01.007"},{"key":"e_1_2_9_11_1","volume-title":"Medtronic\u00a0CRM\u00a0Product Performance Report, Issue 85","year":"2021"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.06.016"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2021.05.012"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2007.05.002"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15493"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1520\/STP161620180033"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.05.014"},{"key":"e_1_2_9_18_1","unstructured":"3830 Technical Manual.\u00a0Medtronic;\u00a02013.\u00a0https:\/\/manuals.medtronic.com\/content\/dam\/emanuals\/crdm\/CONTRIB_157979.pdf"},{"issue":"1","key":"e_1_2_9_19_1","first-page":"156","article-title":"Deep septal deployment of a thin, lumenless pacing lead: a translational cadaver simulation study","volume":"22","author":"Jastrz\u0119bski M","year":"2020","journal-title":"Europace"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.12.029"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15843","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.15843","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15843","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T22:32:33Z","timestamp":1692570753000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.15843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,14]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/jce.15843"],"URL":"https:\/\/doi.org\/10.1111\/jce.15843","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,14]]},"assertion":[{"value":"2022-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}