{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:42:45Z","timestamp":1792014165542,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Sacubitril\/valsartan reduces all\u2010cause mortality in heart failure (HF) patients compared to angiotensin\u2010converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs). ACEIs\/ARBs have been shown to decrease the incidence of atrial fibrillation (AF). We hypothesized sacubitril\u2013valsartan decreases the incidence of AF compared to ACEis\/ARBs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/Clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link> was searched for trials by terms sacubitril\/valsartan, entresto, sacubitril, valsartan. Randomized controlled human trials of sacubitril\/valsartan reporting AF were included. Data were extracted independently by two reviewers. Data was pooled using a random effect model. Publication bias was evaluated by funnel plots.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 11 trials including 11,458 patients on sacubitril\/valsartan and 10,128 patients on ACEI\/ARBs were identified. A total of 284 AF events were reported in the sacubitril\/valsartan group compared to 256 AF events in ACEIs\/ARBs. Patients on sacubitril\/valsartan were as likely as patients on ACEIs\/ARBs to develop AF (pooled odds ratio [OR]\u2009=\u20091.091, 95% confidence interval [CI]\u2009=\u20090.917\u20131.298, <jats:italic>p<\/jats:italic>\u2009=\u2009.324). Six atrial flutter (AFl) events were reported in six trials; 48 out of 9165 patients in the sacubitril\/valsartan group developed AFl compared to 46 out of 8759 in ACEi\/ARBs group. There was no difference in AFl risk between the two groups (pooled OR\u2009=\u20091.028, 95% CI\u2009=\u20090.681\u20131.553, <jats:italic>p<\/jats:italic>\u2009=\u2009.894). Finally, sacubitril\/valsartan did not reduce the risk of atrial arrhythmias (AF\u2009+\u2009AFl) compared to ACEi\/ARBs (pooled OR\u2009=\u20091.081, 95% CI\u2009=\u20090.922\u20131.269, <jats:italic>p<\/jats:italic>\u2009=\u2009.337).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although sacubitril\/valsartan reduces mortality compared to ACEIs\/ARBs in HF patients, they do not reduce AF risk compared to these drugs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15880","type":"journal-article","created":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T08:54:25Z","timestamp":1678006465000},"page":"1037-1042","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of sacubitril\u2013valsartan on the incidence of atrial fibrillation: A meta\u2010analysis"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7474-6647","authenticated-orcid":false,"given":"Zoya","family":"Mohammad","sequence":"first","affiliation":[{"name":"The Department of Medicine and Center of Excellence for Cardiovascular Diseases &amp; Sciences Louisiana State University and Health Science Center  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6828-6154","authenticated-orcid":false,"given":"Javaria","family":"Ahmad","sequence":"additional","affiliation":[{"name":"The Department of Medicine and Center of Excellence for Cardiovascular Diseases &amp; Sciences Louisiana State University and Health Science Center  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Sultan","sequence":"additional","affiliation":[{"name":"The Department of Medicine and Center of Excellence for Cardiovascular Diseases &amp; Sciences Louisiana State University and Health Science Center  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashritha","family":"Penagaluri","sequence":"additional","affiliation":[{"name":"The Department of Medicine and Center of Excellence for Cardiovascular Diseases &amp; Sciences Louisiana State University and Health Science Center  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9637-9507","authenticated-orcid":false,"given":"Daniel","family":"Morin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ochsner Medical Center  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paari","family":"Dominic","sequence":"additional","affiliation":[{"name":"The Department of Medicine and Center of Excellence for Cardiovascular Diseases &amp; Sciences Louisiana State University and Health Science Center  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034755"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409077"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-019-01440-y"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41540-017-0013-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpx111"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61227-6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01285"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-021-10137-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173120"},{"key":"e_1_2_7_11_1","unstructured":"ClinicalTrials.gov. Comparison of sacubitril\/valsartan versus enalapril on effect on NT\u2010probnp in patients stabilized from an acute heart failure episode. Accessed September 25 2022.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02554890"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2076"},{"key":"e_1_2_7_13_1","unstructured":"ClinicalTrials.gov. Study of effects of sacubitril\/valsartan vs. enalapril on aortic stiffness in patients with mild to moderate HF with reduced ejection fraction. Accessed September 25 2022.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02874794"},{"key":"e_1_2_7_14_1","unstructured":"ClinicalTrials.gov. Efficacy and safety of LCZ696 in comparison to Olmesartan in Asian patients with essential hypertension. Accessed October 4 2022.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01785472"},{"key":"e_1_2_7_15_1","unstructured":"ClinicalTrials.gov. Study of the safety and efficacy of LCZ696 on arterial stiffness in elderly patients with hypertension. Accessed October 4 2022.https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT01692301"},{"key":"e_1_2_7_16_1","unstructured":"ClinicalTrials.gov. Efficacy and safety of LCZ696 compared to valsartan on morbidity and mortality in heart failure patients with preserved ejection fraction\u2014ll text view. Accessed October 4 2022.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01920711"},{"key":"e_1_2_7_17_1","unstructured":"ClinicalTrials.gov. A randomized double\u2010blind controlled study comparing LCZ696 to medical therapy for comorbidities in HFPEF patients\u2014full text view.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03066804."},{"key":"e_1_2_7_18_1","unstructured":"ClinicalTrials.gov. Exercise capacity study of LCZ696 vs. enalapril in patients with chronic heart failure and reduced ejection fraction.Accessed October 4 2022.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02768298"},{"key":"e_1_2_7_19_1","unstructured":"ClinicalTrials.gov. LCZ696 compared to valsartan in patients with chronic heart failure and preserved left\u2010ventricular ejection fraction. Accessed October 4 2022.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00887588"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15880","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.15880","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:47:18Z","timestamp":1692578838000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.15880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,16]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/jce.15880"],"URL":"https:\/\/doi.org\/10.1111\/jce.15880","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,16]]},"assertion":[{"value":"2022-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}