{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T10:59:38Z","timestamp":1782989978353,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The prediction of ventricular tachyarrhythmias among patients with implantable cardioverter defibrillators is difficult with available clinical tools. We sought to assess whether in patients with heart failure (HF) and reduced ejection fraction with defibrillators, physiological sensor\u2010based HF status, as summarized by the HeartLogic index, could predict appropriate device therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five hundred and sixty\u2010eight consecutive HF patients with defibrillators (<jats:italic>n<\/jats:italic>\u2009=\u2009158, 28%) or cardiac resynchronization therapy\u2010defibrillators (<jats:italic>n<\/jats:italic>\u2009=\u2009410, 72%) were included in this prospective observational multicenter analysis. The association of both HeartLogic index and its physiological components with defibrillator shocks and overall appropriate therapies was assessed in regression and time\u2010dependent Cox models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over a follow\u2010up of 25 (15\u201335) months, 122 (21%) patients received an appropriate device therapy (shock, <jats:italic>n<\/jats:italic>\u2009=\u200974, 13%), while the HeartLogic index crossed the threshold value (alert, HeartLogic\u2009\u2265\u200916) 1200 times (0.71 alerts\/patient\u2010year) in 370 (65%) subjects. The occurrence of \u22651 HeartLogic alert was significantly associated with both appropriate shocks (Hazard ratios [HR]: 2.44, 95% confidence interval [CI]: 1.49\u20133.97, <jats:italic>p<\/jats:italic>\u2009=\u2009.003), and any appropriate defibrillator therapies. In multivariable time\u2010dependent Cox models, weekly IN\u2010alert state was the strongest predictor of appropriate defibrillator shocks (HR: 2.94, 95% CI: 1.73\u20135.01, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and overall therapies. Compared with stable patients, patients with appropriate shocks had significantly higher values of HeartLogic index, third heart sound amplitude, and resting heart rate 30\u201360 days before device therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The HeartLogic index is an independent dynamic predictor of appropriate defibrillator therapies. The combined index and its individual physiological components change before the arrhythmic event occurs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15898","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T15:47:35Z","timestamp":1680191255000},"page":"1257-1267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Implantable defibrillator\u2010detected heart failure status predicts ventricular tachyarrhythmias"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1924-6548","authenticated-orcid":false,"given":"Paolo","family":"Compagnucci","sequence":"first","affiliation":[{"name":"Cardiology and Arrhythmology Clinic University Hospital \u201cAzienda Ospedaliero\u2010Universitaria delle Marche\u201d Ancona Italy"},{"name":"Department of Biomedical Sciences and Public Health Marche Polytechnic University Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Casella","sequence":"additional","affiliation":[{"name":"Cardiology and Arrhythmology Clinic University Hospital \u201cAzienda Ospedaliero\u2010Universitaria delle Marche\u201d Ancona Italy"},{"name":"Department of Clinical, Special and Dental Sciences Marche Polytechnic University Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valter","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Elettrofisiologia Studio e Terapia delle Aritmie,\u201d Monaldi Hospital Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Franculli","sequence":"additional","affiliation":[{"name":"OO. RR. San Giovanni di Dio Ruggi d'Aragona Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Vitali","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Sant'Anna University Hospital University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Santini","sequence":"additional","affiliation":[{"name":"\u201cGiovan Battista Grassi\u201d Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Savarese","sequence":"additional","affiliation":[{"name":"S. Giovanni Battista Hospital Foligno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo Ezio","family":"Santobuono","sequence":"additional","affiliation":[{"name":"Policlinico di Bari University of Bari Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Chianese","sequence":"additional","affiliation":[{"name":"S. Anna e S. Sebastiano Hospital Caserta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Lavalle","sequence":"additional","affiliation":[{"name":"Policlinico Umberto I Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Amellone","sequence":"additional","affiliation":[{"name":"\u201cMaria Vittoria\u201d Hospital Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Pecora","sequence":"additional","affiliation":[{"name":"Fondazione Poliambulanza Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimondo","family":"Calvanese","sequence":"additional","affiliation":[{"name":"Ospedale del Mare Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Stronati","sequence":"additional","affiliation":[{"name":"Cardiology and Arrhythmology Clinic University Hospital \u201cAzienda Ospedaliero\u2010Universitaria delle Marche\u201d Ancona Italy"},{"name":"Department of Biomedical Sciences and Public Health Marche Polytechnic University Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2629-4372","authenticated-orcid":false,"given":"Amato","family":"Santoro","sequence":"additional","affiliation":[{"name":"Cardiovascular and Thoracic Department Azienda Ospedaliera Universitaria Senese Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3617-2739","authenticated-orcid":false,"given":"Matteo","family":"Ziacchi","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine, Institute of Cardiology, Policlinico S. 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