{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:39:27Z","timestamp":1791319167569,"version":"4.3.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T00:00:00Z","timestamp":1682208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The assessment of the ventricular myocardial substrate critically depends on the size of mapping electrodes, their orientation with respect to wavefront propagation, and interelectrode distance. We conducted a dual\u2010center study to evaluate the impact of microelectrode mapping in patients undergoing catheter ablation (CA) of ventricular tachycardia (VT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We included 21 consecutive patients (median age, 68 [12], 95% male) with structural heart disease undergoing CA for electrical storm (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914) or recurrent VT (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097) using the QDOT Micro catheter and a multipolar catheter (PentaRay,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099). The associations of peak\u2010to\u2010peak maximum standard bipolar (BV\n                      <jats:sub>c<\/jats:sub>\n                      ) and minibipolar (PentaRay, BV\n                      <jats:sub>p<\/jats:sub>\n                      ) with microbipolar (BV\n                      <jats:sub>\u03bcMax<\/jats:sub>\n                      ) voltages were respectively tested in sinus rhythm with mixed effect models. Furthermore, we compared the features of standard bipolar (BE) and microbipolar (\u03bcBE) electrograms in sinus rhythm at sites of termination with radiofrequency energy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      BV\n                      <jats:sub>\u03bcMax<\/jats:sub>\n                      was moderately associated with both BV\n                      <jats:sub>c<\/jats:sub>\n                      (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009.85,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01) and BV\n                      <jats:sub>p<\/jats:sub>\n                      (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009.56,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01). BV\n                      <jats:sub>\u03bcMax<\/jats:sub>\n                      was 0.98 (95% CI: 0.93\u22121.04,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01) mV larger than corresponding BV\n                      <jats:sub>c<\/jats:sub>\n                      , and 0.27 (95% CI: 0.16\u22120.37,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01) mV larger than matching BVp in sinus rhythm, with higher percentage differences in low voltage regions, leading to smaller endocardial dense scar (2.3 [2.7] vs. 12.1 [17] cm\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01) and border zone (3.2 [7.4] vs. 4.8 [20.1] cm\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.03) regions in microbipolar maps compared to standard bipolar maps. Late potentials areas were nonsignificantly greater in microelectrode maps, compared to standard electrode maps. At sites of VT termination (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914), \u03bcBE were of higher amplitude (0.9 [0.8] vs. 0.4 [0.2] mV,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01), longer duration (117 [66] vs. 74 [38] ms,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01), and with greater number of peaks (4 [2] vs. 2 [1],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01) in sinus rhythm compared to BE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>microelectrode mapping is more sensitive than standard bipolar mapping in the identification of viable myocytes in SR, and may facilitate recognition of targets for CA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.15908","type":"journal-article","created":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T06:44:17Z","timestamp":1682232257000},"page":"1216-1227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Microelectrode voltage mapping for substrate assessment in catheter ablation of ventricular tachycardia: A dual\u2010center experience"],"prefix":"10.1111","volume":"34","author":[{"given":"Antonio","family":"Dello Russo","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences and Public Health Marche Polytechnic University Ancona Italy"},{"name":"Cardiology and Arrhythmology Clinic University Hospital \u201cOspedali Riuniti\u201d Ancona 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