{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:43:31Z","timestamp":1793094211667,"version":"4.5.0"},"reference-count":7,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Electrophysiological testing has been proposed in the latest European Society of Cardiology (ESC) guidelines for cardiac pacing to identify left bundle branch block (LBBB) patients with infrahisian conduction delay (IHCD) after transcatheter aortic valve replacement (TAVR). While in general IHCD is defined by a His\u2010ventricular (HV) interval of &gt;55\u2009ms, a cut\u2010off of \u226570\u2009ms to trigger pacemaker (PM) implantation has been proposed in the latest ESC guidelines. The ventricular pacing (VP) burden during follow\u2010up in such patients is largely unknown. As such, we aimed to assess the VP burden during follow\u2010up of patients receiving PM therapy for LBBB after TAVR based on an HV interval &gt; 55 ms and \u226570\u2009ms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients with new\u2010onset or pre\u2010existing LBBB after undergoing TAVR at a tertiary referral center underwent EP testing the day after TAVR. In patients with a prolonged HV interval (&gt;55\u2009ms), PM implantation was performed by a trained electrophysiologist in a standardized fashion. All devices were programmed to avoid unnecessary VP by specific algorithms (e.g., AAI\u2010DDD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>701 patients underwent TAVR at the University Hospital of Basel. One hundred seventy\u2010seven patients presented with new\u2010onset or pre\u2010existing LBBB the day following TAVR and underwent EP testing. An HV interval\u2009&gt;\u200955\u2009ms was found in 58 patients (33%) and an HV interval\u2009\u2265\u200970\u2009ms in 21 patients (12%). 51 patients (mean age 84\u2009\u00b1\u20096.2 years, 45% women) agreed to receive a PM, out of which 20 (39%) patients had an HV Interval over 70\u2009ms. Atrial fibrillation was present in 53% of the patients. A dual chamber PM was implanted in 39 (77%), and a single chamber PC in 12 (23%) patients, respectively. Median follow\u2010up was 21 months. The median VP burden overall was 3%. The median VP burden was not significantly different between patients with an HV\u2009\u2265\u200970 ms (6.5 [0.8\u221252]) and those with an HV between 55 and 69 ms (2 [0\u221217], <jats:italic>p<\/jats:italic>\u2009=\u2009.23). 31% of patients demonstrated a VP burden\u2009&lt;\u20091%, 27% 1%\u22125% and 41%\u2009&gt;\u20095%. The median HV intervals in patients with VP burdens\u2009&lt;\u20091%, 1%\u22125% and &gt;5% were 66 (IQR 62\u221270)\u2009ms, 66 (IQR 63\u221274)\u2009ms and 68 (IQR 60\u221272)\u2009ms, respectively, <jats:italic>p<\/jats:italic>\u2009=\u2009.52. When only assessing patients with an HV interval 55\u221269\u2009ms, 36% demonstrated a VP burden of &lt;1%, 29% of 1%\u22125% and 35% of &gt;5%. In patients with an HV Interval\u2009\u2265\u200970\u2009ms, 25% demonstrated a VP burden\u2009&lt;\u20091%, 25% of 1%\u22125% and 50% of &gt;5% %, <jats:italic>p<\/jats:italic>\u2009=\u2009.64 (Figure).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with LBBB after TAVR and IHCD defined by an HV interval\u2009&gt;\u200955\u2009ms, VP burden is relevant in a non\u2010negligible amount of patients during follow\u2010up. Further studies are warranted to define the optimal cut\u2010off value for the HV interval or to develop risk models incorporating HV measurements and other risk factors to trigger PM implantation in patients with LBBB after TAVR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15920","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T18:49:00Z","timestamp":1683312540000},"page":"1464-1468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Ventricular pacing burden in patients with left bundle branch block after transcatheter aortic valve replacement therapy"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2377-2893","authenticated-orcid":false,"given":"Teodor","family":"Serban","sequence":"first","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7122-021X","authenticated-orcid":false,"given":"Sven","family":"Knecht","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne du Fay","family":"du Lavallaz","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Nestelberger","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Leibundgut","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Osswald","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Schaer","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Sticherling","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"K\u00fchne","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9751-0557","authenticated-orcid":false,"given":"Patrick","family":"Badertscher","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd9100324"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.026239"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab364"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.10.023"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-016-0218-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv137"},{"key":"e_1_2_9_8_1","first-page":"768","article-title":"Electrophysiological study of atrio\u2010ventricular block and ventricular conduction defects. Prognostic and therapeutical implications","volume":"14","author":"Gronda M","year":"1984","journal-title":"G Ital Cardiol"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15920","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T21:52:07Z","timestamp":1692481927000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.15920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,5]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/jce.15920"],"URL":"https:\/\/doi.org\/10.1111\/jce.15920","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,5]]},"assertion":[{"value":"2023-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}