{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:45:47Z","timestamp":1789573547408,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It is unclear if the location of implantation of the leadless pacemaker (LP) makes a difference in the incidence of pacing\u2010induced cardiomyopathy (PICM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this study was to compare the incidence of PICM based on the location of implantation of LP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 358 consecutive patients [women: 171 (48%), mean age: 73\u2009\u00b1\u200915\u2009years] with left ventricular ejection fraction (EF)\u2009&gt;\u200950%, who received an\u00a0LP (Micra) between January 2017 and June 2022, formed the study cohort.\u00a0Micra\u2010AV and Micra\u2010VR were implanted in 122 (34%) and 236 (66%) patients, respectively. Fluoroscopically, the location of implantation of LP in the interventricular septum (IS) was divided into two equal halves (apex\/apical septum [AS]\u00a0and mid\/high septum [HS]). During follow\u2010up, PICM was defined as an EF drop of \u226510%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LP was implanted in 109 (34%) and 249 (66%) patients at AS and HS locations, respectively. During a mean 18\u2009\u00b1\u20098 months follow\u2010up, 28 patients (7.8%) developed PICM. Among the 249 patients with HS placement of LP, 10 (4%) developed PICM, whereas among the 109 patients with AS placement of LP, 18 (16.5%) developed PICM (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.002). AS location was associated with a higher risk of PICM compared to HS locations (adjusted hazard ratio: 4.42,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AS location of LP was associated with a higher risk of PICM compared to HS placement. Larger randomized studies are needed to confirm our findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.15925","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T23:46:45Z","timestamp":1683762405000},"page":"1418-1426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Anatomical location of leadless pacemaker and the risk of pacing\u2010induced cardiomyopathy"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0939-140X","authenticated-orcid":false,"given":"Ghanshyam","family":"Shantha","sequence":"first","affiliation":[{"name":"Department of Cardiac Electrophysiology Wake Forest University Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Brock","sequence":"additional","affiliation":[{"name":"Department of Cardiac Electrophysiology Wake Forest University Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Singleton","sequence":"additional","affiliation":[{"name":"Wellspan Hospital York Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Kozak","sequence":"additional","affiliation":[{"name":"Department of Cardiac Electrophysiology Wake Forest University Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Bodziock","sequence":"additional","affiliation":[{"name":"Department of Cardiac Electrophysiology Wake Forest University Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Bradford","sequence":"additional","affiliation":[{"name":"Department of Cardiac Electrophysiology Wake Forest University Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9560-1102","authenticated-orcid":false,"given":"Abhishek","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"Department of Cardiac Electrophysiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson J.","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Electrophysiology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naga Venkata K.","family":"Pothineni","sequence":"additional","affiliation":[{"name":"Kansas City Heart Rhythm Institute  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Hranitzky","sequence":"additional","affiliation":[{"name":"Department of Cardiac University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Whalen","sequence":"additional","affiliation":[{"name":"Department of Cardiac Electrophysiology Wake Forest University Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0664-7828","authenticated-orcid":false,"given":"Prashant D.","family":"Bhave","sequence":"additional","affiliation":[{"name":"Department of Cardiac Electrophysiology Wake Forest University Winston\u2010Salem North Carolina 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