{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:07:23Z","timestamp":1791014843654,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In patients receiving conduction system pacing (CSP), it is not well established how to program the sensed atrioventricular delay (sAVD), with respect to the type of capture obtained (selective, nonselective His\u2010bundle [HB]\u00a0capture or left bundle branch [LBB]\u00a0capture). The aim of this study was to acutely assess the effectiveness of an electrophysiology (EP)\u2010guided method for sAVD optimization by comparing it with the echocardiogram\u2010guided optimization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Consecutive patients undergoing HB or LBB pacing were enrolled. The EP\u2010guided sAVD was defined as the sAVD leading to a PR interval of 150\u2009ms on surface electrocardiogram (ECG). In HB pacing patients, EP\u2010guided sAVD was obtained subtracting the time from the onset of the P wave on ECG to the local atrial electrogram (EGM) recorded by the atrial lead (right atrial sensing latency, RASL) and the His\u2010ventricular interval from 150\u2009ms; in LBB pacing patients, subtracting RASL from 150\u2009ms. Transmitral flow assessment by pulsed wave Doppler was used to find the echo\u2010optimized sAVD by a modified iterative method. The discordance between the EP\u2010guided and the echo\u2010optimized sAVD was recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010one patients were enrolled: 12 with selective, 32 nonselective HB capture, and 27 LBB capture. Overall, the rate of concordance between the EP\u2010guided and the echo\u2010optimized sAVD was 71.8%, with no significant differences between the three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In CSP patients, an optimal sAVD can be programmed, in more than 70% of cases, considering only simple EGM intervals to obtain a physiological PR interval on surface ECG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15927","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T03:46:09Z","timestamp":1683776769000},"page":"1441-1451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Optimization of the atrioventricular delay in conduction system pacing"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0292-5202","authenticated-orcid":false,"given":"Giovanni","family":"Coluccia","sequence":"first","affiliation":[{"name":"Cardiology Unit \u201cCard. 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Panico\u201d Hospital Tricase Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Dell'Era","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Maggiore della Carit\u00e0 Hospital University of Eastern Piedmont Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Ghiglieno","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Maggiore della Carit\u00e0 Hospital University of Eastern Piedmont Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"De Vecchi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Maggiore della Carit\u00e0 Hospital University of Eastern Piedmont Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Spinoni","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Maggiore della Carit\u00e0 Hospital University of Eastern Piedmont Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Santagostino","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Maggiore della Carit\u00e0 Hospital University of Eastern Piedmont Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Guido","sequence":"additional","affiliation":[{"name":"Cardiology Unit \u201cCard. 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