{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:46:10Z","timestamp":1787611570664,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Radiofrequency ablation (RFA) for atrial fibrillation (AF) has been associated with variable incidence (0.88%\u201310%) of pericarditis manifested as chest pain, possibly more prevalent with the advent of high\u2010power short\u2010duration (HPSD) ablation. This has led to the widespread use of colchicine in preventative protocols for postablation pericarditis. However, the efficacy of preventative colchicine has not been validated yet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy of a routine postoperative colchicine regimen (0.6\u2009mg\u2009twice a day for 14 days post\u2010AF ablation) for prevention of postablation pericarditis in patients undergoing HPSD ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We retrospectively evaluated consecutive single\u2010operator HPSD AF ablation procedures at our institution from June 2019 to July 2022. A colchicine protocol was introduced in June 2021 for the prevention of postablation pericarditis. All ablations were performed with 50\u2009watts. Patients were divided into colchicine and noncolchicine groups. We recorded incidence of postablation chest pain, emergency room (ER) visit for chest pain, pericardial effusion, pericardiocentesis, any ER visit, hospitalization, AF recurrence, and cardioversion for AF within the first 30 days following ablation. We also recorded colchicine\u2010related side effects and medication compliance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and ninety\u2010four consecutive HPSD AF ablation patients were screened for the study. After implementing the prespecified exclusion criteria, a total of 205 patients were included in the final analysis, yielding 101 patients in the colchicine group and 104 patients in the noncolchicine group. Both groups were well\u2010matched for demographic and procedural parameters. There was no significant difference in postablation chest pain (9.9% vs. 8.6%, <jats:italic>p<\/jats:italic>\u2009=\u2009.7), pericardial effusion (2.9% vs. 0.9%, <jats:italic>p<\/jats:italic>\u2009=\u2009.1), ER visits (11.9% vs. 12.5%, <jats:italic>p<\/jats:italic>\u2009=\u2009.2), 30\u2010day hospitalization for AF recurrence (0.9% vs. 0.96%, <jats:italic>p<\/jats:italic>\u2009=\u2009.3), and 30\u2010day need for cardioversion for AF (3.9% vs. 5.7%, <jats:italic>p<\/jats:italic>\u2009=\u2009.2). Fifteen (15) patients had severe colchicine\u2010related diarrhea, out of which 12 discontinued it prematurely. There were no major procedural complications in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this single\u2010operator retrospective analysis, prophylactic colchicine was not associated with significant reduction in the incidence of postablation chest pain, pericarditis, 30\u2009day hospitalization, ER visits, or AF recurrence or need of cardioversion within first 30 days after HPSD ablation for AF. However, its usage was associated with significant diarrhea. This study concludes no additional advantage of prophylactic use of colchicine after HPSD AF ablation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15941","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T11:06:23Z","timestamp":1685099183000},"page":"1370-1376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Colchicine usage for prevention of post atrial fibrillation ablation pericarditis in patients undergoing high\u2010power short\u2010duration ablation"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5800-9855","authenticated-orcid":false,"given":"Arshad Muhammad","family":"Iqbal","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine University of Missouri School of Medicine Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Missouri School of Medicine  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Gautam","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Missouri School of Medicine Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"32","article-title":"Updated worldwide survey on the methods, efficacy, and safety of catheter ablation for human atrial fibrillation","volume":"3","author":"Cappato 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