{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T01:23:59Z","timestamp":1783387439304,"version":"3.54.6"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T00:00:00Z","timestamp":1686355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The electrophysiological responses of the left atrial appendage (LAA) during pulsed\u2010field electrical isolation have not been established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to investigate the electrical responses of the LAA during pulsed\u2010field electrical isolation using a novel device and their relations to acute isolation success.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six canines were enrolled. The E\u2010SeaLA\u2122 device, which is able to perform LAA occlusion and ablation simultaneously, was deployed into the LAA ostium. LAA potentials (LAAp) were mapped via a mapping catheter, and the LAAp recovery time (LAAp RT, the time between the last pulsed spike and the first recovered LAAp) was measured after pulsed\u2010train delivery. The initial pulse index (PI, corelated to pulsed\u2010field intensity) was adjusted during the ablation procedure until LAAEI was achieved. Acute LAA electrical isolation (LAAEI) success was defined as LAAp disappearance or exit and entrance conduction block, confirmed through a drug test and a 60\u2010minute waiting period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>All canines achieved successful LAA occlusion without peri\u2010device leaks. Acute LAA electrical isolation (LAAEI) was achieved in five out of six canines (5\/6, 83.3%). Very late LAAp recurrence (LAAp RT\u2009&gt;\u2009600\u2009s) was observed during PFA. Early recurrence (LAAp RT\u2009&lt;\u200930\u2009s) was observed in two canines (2\/6, 33.3%) post\u2010PFA. Intermediate recurrence (LAAp RT\u2009~\u2009120\u2009s) was observed in three canines (3\/6, 50%) post\u2010PFA. The two canines with intermediate recurrence achieved LAAEI with higher PI ablations. The one canine with early LAAp recurrence had a peri\u2010device leak and achieved LAAEI by the same PI after replacing with a larger size device and eliminating the peri\u2010device leak. Another canine with early recurrence (1\/6, 16.7%) failed to achieve LAAEI due to epicardial connection with persistent left superior vena cava. No coronary spasm, stenosis or other complications were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that with proper device\u2010tissue contact and pulse intensity, LAAEI can be achieved using this novel device without serious complications. The LAAp RT patterns observed in this study could inform and guide the adjustment of the ablation strategy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15962","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T21:22:27Z","timestamp":1686432147000},"page":"1529-1538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Electrophysiological responses of the left atrial appendage during pulsed\u2010field electrical isolation utilizing a novel device in a canine model"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0328-8217","authenticated-orcid":false,"given":"Jiangang","family":"Xu","sequence":"first","affiliation":[{"name":"Hangzhou Dinova Electrophysiology Medical Technology Co., Ltd Hangzhou 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Electrophysiology Medical Technology Co., Ltd Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Arrhythmia, National Center for Cardiovascular Diseases, Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7323-3698","authenticated-orcid":false,"given":"Min","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Arrhythmia, National Center for Cardiovascular Diseases, Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 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