{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:23:46Z","timestamp":1747185826700,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,7,2]],"date-time":"2023-07-02T00:00:00Z","timestamp":1688256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Dynamic ECG changes in Brugada syndrome (BrS) are influenced by several factors, may not be apparent, and can be unmasked by a drug test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Four of six patients with nondiagnostic Brugada ECG index patterns underwent a dextrose\u2010insulin challenge test that resulted in J\u2010ST segment elevation and triggered arrhythmias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Insulin action may be due in part to an outward shift in the K<jats:sup>+<\/jats:sup> current at the end of action potential phase 1 and the dispersion of repolarization, leading to local re\u2010entry with arrhythmogenicity. This effect is likely a phenomenon\u2010specific to BrS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15983","type":"journal-article","created":{"date-parts":[[2023,7,2]],"date-time":"2023-07-02T12:19:20Z","timestamp":1688300360000},"page":"1776-1780","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Arrhythmias induced by dextrose\u2010insulin challenge test in nondiagnostic Brugada ECG patterns"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5150-743X","authenticated-orcid":false,"given":"Enrique","family":"Vel\u00e1zquez\u2010Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Servicio de Electrofisiolog\u00eda, Unidad M\u00e9dica de Alta Especialidad Hospital de Cardiolog\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social Universidad Nacional Aut\u00f3noma de M\u00e9xico Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6389-1424","authenticated-orcid":false,"given":"Jos\u00e9 Paz Marcelo","family":"Jim\u00e9nez\u2010Cruz","sequence":"additional","affiliation":[{"name":"Servicio de Electrofisiolog\u00eda, Unidad M\u00e9dica de Alta Especialidad Hospital de Cardiolog\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social Universidad Nacional Aut\u00f3noma de M\u00e9xico Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4157(83)90013-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00074"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2016.08.007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.06.004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.09.060"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eup189"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp326"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.10.043"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2001.00680.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.03.015"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.15.1660"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.51.159"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eur148"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2003.02389.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2003.00044.x"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T05:37:42Z","timestamp":1692337062000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.15983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,2]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/jce.15983"],"URL":"https:\/\/doi.org\/10.1111\/jce.15983","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"type":"print","value":"1045-3873"},{"type":"electronic","value":"1540-8167"}],"subject":[],"published":{"date-parts":[[2023,7,2]]},"assertion":[{"value":"2022-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}