{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:01:58Z","timestamp":1791388918958,"version":"4.3.3"},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Pulsed\u2010field ablation (PFA) and the multielectrode radiofrequency balloon (RFB) are two novel ablation technologies to perform pulmonary vein isolation (PVI). It is currently unknown whether these technologies differ in lesion formation and lesion extent. We compared the acute lesion extent after PVI induced by PFA and RFB by measuring low\u2010voltage area in high\u2010density maps and the release of biomolecules reflecting cardiac injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PVI was performed with a pentaspline catheter (FARAPULSE) applying PFA or with the compliant multielectrode RFB (HELIOSTAR). Before and after PVI high\u2010density mapping with CARTO 3 was performed. In addition, blood samples were taken before transseptal puncture and after post\u2010PVI remapping and serum concentrations of high\u2010sensitive Troponin I were quantified by immunoassay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty patients undergoing PVI by PFA (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200928, age 69\u2009\u00b1\u200912 year, 60% males, 39.3% persistent atrial fibrillation [AF]) or RFB (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200932, age 65\u2009\u00b1\u200913 year, 53% males, 21.9% persistent AF) were evaluated. Acute PVI was achieved in all patients in both groups. Mean number of PFA pulses was 34.2\u2009\u00b1\u20094.5 and mean number RFB applications was 8.5\u2009\u00b1\u20093 per patient. Total posterior ablation area was significantly larger in PFA (20.7\u2009\u00b1\u20097.7\u2009cm\u00b2) than in RFB (7.1\u2009\u00b1\u20092.09\u2009cm\u00b2;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Accordingly, posterior ablation area for each PV resulted in larger lesions after PFA versus RFB (LSPV 5.2\u2009\u00b1\u20092.7 vs. 1.9\u2009\u00b1\u20090.8\u2009cm\u00b2, LIPV 5.5\u2009\u00b1\u20092.3 vs. 1.9\u2009\u00b1\u20090.8\u2009cm\u00b2, RSPV 4.7\u2009\u00b1\u20091.9 vs. 1.6\u2009\u00b1\u20090.5\u2009cm\u00b2, RIPV 5.3\u2009\u00b1\u20092.1 vs. 1.6\u2009\u00b1\u20090.7\u2009cm,\u00b2 respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). In a subset of 38 patients, increase of hsTropI was higher after PFA (625\u2009\u00b1\u2009138\u2009pg\/mL,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200928) versus RFB (148\u2009\u00b1\u200936\u2009pg\/mL,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.049) supporting the evidence of larger lesion extent by PFA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PFA delivers larger acute lesion areas and higher troponin release upon successful PVI than multielectrode RFB\u2010based PVI in this single\u2010center series.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.16001","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T17:10:04Z","timestamp":1689873004000},"page":"1802-1807","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Acute lesion extension following pulmonary vein isolation with two novel single shot devices: Pulsed field ablation versus multielectrode radiofrequency balloon"],"prefix":"10.1111","volume":"34","author":[{"given":"Ilaria","family":"My","sequence":"first","affiliation":[{"name":"Department of Cardiology University Heart &amp; Vascular Center Hamburg, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"DZHK, Partner Site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3799-7962","authenticated-orcid":false,"given":"Marc D.","family":"Lemoine","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart &amp; Vascular Center Hamburg, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"DZHK, Partner Site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahi","family":"Butt","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart &amp; Vascular Center Hamburg, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"DZHK, Partner Site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Mencke","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart &amp; Vascular Center Hamburg, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"DZHK, Partner Site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian W.","family":"Loeck","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart &amp; Vascular Center Hamburg, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"DZHK, Partner Site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Obergassel","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart &amp; Vascular Center Hamburg, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"DZHK, Partner Site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rottner","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart &amp; Vascular Center Hamburg, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"DZHK, Partner Site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6302-8671","authenticated-orcid":false,"given":"Jan\u2010Per","family":"Wenzel","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart &amp; Vascular Center Hamburg, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"DZHK, Partner Site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Schleberger","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart &amp; Vascular Center Hamburg, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"DZHK, Partner Site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Moser","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart &amp; Vascular Center Hamburg, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"DZHK, Partner Site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7310-6111","authenticated-orcid":false,"given":"Fabian","family":"Moser","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart &amp; Vascular Center Hamburg, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"DZHK, Partner Site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulus","family":"Kirchhof","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart &amp; Vascular Center Hamburg, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"DZHK, Partner Site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"},{"name":"Institute of Cardiovascular Sciences University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Reissmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart &amp; Vascular Center Hamburg, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"DZHK, Partner Site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifan","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart &amp; Vascular Center Hamburg, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"DZHK, Partner Site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3457-0936","authenticated-orcid":false,"given":"Andreas","family":"Rillig","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart &amp; Vascular Center Hamburg, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"DZHK, Partner Site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6818-6396","authenticated-orcid":false,"given":"Andreas","family":"Metzner","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart &amp; Vascular Center Hamburg, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"DZHK, Partner Site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602014"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.119.008303"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2021.02.014"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-022-02091-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.119.007541"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14476"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaa382"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euab150"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2022.05.020"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.122.011598"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2021.02.020"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000922"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac211"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac284"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.16001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T09:09:53Z","timestamp":1694768993000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.16001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,20]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/jce.16001"],"URL":"https:\/\/doi.org\/10.1111\/jce.16001","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,20]]},"assertion":[{"value":"2023-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}