{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T13:37:23Z","timestamp":1770039443444,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In an aging population with cardiac implantable electronic devices, an increasing number of octo\u2010 and even nonagenarians present for lead extraction procedures. Those patients are considered at increased risk for surgical procedures including lead extraction. Here, we investigated safety and efficacy of transvenous lead extraction in a large patient cohort of octo\u2010 and nonagenarians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>A subgroup analysis of all patients aged \u226580 years (<jats:italic>n<\/jats:italic>\u2009=\u2009499) in the German Laser Lead Extraction Registry (GALLERY) was performed. Outcomes were compared to the nonoctogenarians from the registry. Primary extraction method was Laser lead extraction, with additional use of mechanical rotational sheaths or femoral snares, if necessary. An analysis of patient\u2010 and device characteristics, as well as an assessment of predictors for adverse events via multivariate analyses was conducted. Mean patients age was 84.3\u2009\u00b1\u20093.7 years in the octogenarians group and 64.1\u2009\u00b1\u200912.4 years in the nonoctogenarians group. The median lead dwell time was 118.0 months (78; 167) and 92.0 months [60; 133], <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001 in the octogenarians and nonoctogenarians group, respectively. Clinical procedural success rate was achieved in 97.6% of the cases in octogenarians and 97.9% in nonoctogenarians (<jats:italic>p<\/jats:italic>\u2009=\u2009.70). Overall complication rate was 4.4% in octogenarians and 4.3% in nonoctogenarians (0.91). In octogenarians procedure\u2010related mortality was 0.8% and all\u2010cause in\u2010hospital mortality was 5.4%, while in nonoctogenarians, procedure related and all\u2010cause in\u2010hospital mortality were 0.5% and 3.1%, respectively. A body mass index (BMI) &lt;20\u2009kg\/m<jats:sup>2<\/jats:sup>, was the only statistically significant predictor for procedure\u2010related complications in octogenarians, while systemic infection, BMI \u226420\u2009kg\/m<jats:sup>2<\/jats:sup>, procedural complications and chronic kidney disease were predictors for in\u2010hospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Laser lead extraction in octo\u2010 and nonagenarians is safe and effective. BMI \u226420\u2009kg\/m<jats:sup>2<\/jats:sup> was the only statistically significant predictor for procedural complications. According to our data, advanced age should not be considered as contraindication for laser lead extraction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16018","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T13:33:40Z","timestamp":1690378420000},"page":"1951-1960","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Laser lead extraction in octo\u2010 and nonagenarians. A subgroup analysis from the GALLERY registry"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8747-166X","authenticated-orcid":false,"given":"Simon","family":"Pecha","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart &amp; Vascular Center Hamburg University Hospital Eppendorf Hamburg Germany"},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6373-7382","authenticated-orcid":false,"given":"Da\u2010Un","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Cardiology &amp; Critical Care Medicine Asklepios Klinik St. Georg Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9832-0285","authenticated-orcid":false,"given":"Heiko","family":"Burger","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Kerckhoff\u2010Klinik Bad Nauheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Osswald","sequence":"additional","affiliation":[{"name":"Division of Electrophysiological Surgery Johanniter\u2010Hospital Duisburg\u2010Rheinhausen Duisburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naser","family":"Ghaffari","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Helios Clinic for Heart Surgery Karlsruhe Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Knaut","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery University Heart Center Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Reichenspurner","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart &amp; Vascular Center Hamburg University Hospital Eppendorf Hamburg Germany"},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Willems","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"},{"name":"Department of Cardiology &amp; Critical Care Medicine Asklepios Klinik St. Georg Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Butter","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Brandenburg Bernau Neuruppin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer","family":"Hakmi","sequence":"additional","affiliation":[{"name":"Department of Cardiology &amp; Critical Care Medicine Asklepios Klinik St. Georg Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"GALLERY 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