{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:21:25Z","timestamp":1768011685683,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the association of cardiac resynchronization therapy (CRT) on outcomes among participants with and without a history of atrial fibrillation (AF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Individual\u2010patient\u2010data from four randomized trials investigating CRT\u2010Defibrillators (COMPANION, MADIT\u2010CRT, REVERSE) or CRT\u2010Pacemakers (COMPANION, MIRACLE) were analyzed. Outcomes were time to a composite of heart failure hospitalization or all\u2010cause mortality or to all\u2010cause mortality alone. The association of CRT on outcomes for patients with and without a history of AF was assessed using a Bayesian\u2010Weibull survival regression model adjusting for baseline characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 3964 patients included, 586 (14.8%) had a history of AF; 2245 (66%) were randomized to CRT. Overall, CRT reduced the risk of the primary composite endpoint (hazard ratio [HR]: 0.69, 95% credible interval [CI]: 0.56\u20130.81). The effect was similar (posterior probability of no interaction\u2009=\u20090.26) in patients with (HR: 0.78, 95% CI: 0.55\u20131.10) and without a history of AF (HR: 0.67, 95% CI: 0.55\u20130.80). In these four trials, CRT did not reduce mortality overall (HR: 0.82, 95% CI: 0.66\u20131.01) without evidence of interaction (posterior probability of no interaction\u2009=\u20090.14) for patients with (HR: 1.09, 95% CI: 0.70\u20131.74) or without a history of AF (HR: 0.70, 95% CI: 0.60\u20130.97).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The association of CRT on the composite endpoint or mortality was not statistically different for patients with or without a history of AF, but this could reflect inadequate power. Our results call for trials to confirm the benefit of CRT recipients with a history of AF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16022","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T09:14:24Z","timestamp":1690794864000},"page":"1914-1924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cardiac resynchronization therapy in patients with a prior history of atrial fibrillation: Insights from four major clinical trials"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7287-4191","authenticated-orcid":false,"given":"Frederik","family":"Dalgaard","sequence":"first","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham North Carolina USA"},{"name":"Department of Cardiology Herlev and Gentofte Hospital Copenhagen Denmark"},{"name":"Department of Medicine Nyk\u00f8bing Falster Sygehus Nyk\u00f8bing Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marat","family":"Fudim","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham North Carolina USA"},{"name":"Division of Cardiology Duke University School of Medicine Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana M.","family":"Al\u2010Khatib","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham North Carolina USA"},{"name":"Division of Cardiology Duke University School of Medicine Durham North Carolina USA"},{"name":"Department of Medicine Duke University School of Medicine Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5791-1954","authenticated-orcid":false,"given":"Daniel J.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham North Carolina USA"},{"name":"Division of Cardiology Duke University School of Medicine Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William T.","family":"Abraham","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine The Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G. 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