{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T08:23:35Z","timestamp":1788942215882,"version":"build-2803163510"},"reference-count":9,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Variants of cardiomyopathy genes in patients with nonischemic cardiomyopathy (NICM) generate various phenotypes of cardiac scar and delayed enhancement cardiac magnetic resonance (DE\u2010CMR) imaging which may impact ventricular tachycardia (VT) management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The objective was to compare the findings of cardiomyopathy genetic testing on DE\u2010CMR imaging and long\u2010term outcomes among patients with NICM undergoing VT ablation procedures. Image phenotyping and genotyping were performed in a consecutive series of patients referred for VT ablation and correlated to survival free of VT. Scar depth index (SDI) (% of scar at 0\u20103\u2009mm, 3\u20105\u2009mm and &gt;5\u2009mm projected on the closest endocardial surface) was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010three patients were included (11 women, 55\u2009\u00b1\u200914 years, ejection fraction (EF) 45\u2009\u00b1\u200916%) and were followed for 3.4\u2009\u00b1\u20092.9 years. Pathogenic variants (PV) were identified in 16 patients (37%) in the following genes: <jats:italic>LMNA (n<\/jats:italic>\u2009=\u2009<jats:italic>5)<\/jats:italic>, <jats:italic>TTN (n<\/jats:italic>\u2009=\u2009<jats:italic>5)<\/jats:italic>, <jats:italic>DSP (n<\/jats:italic>\u2009=\u2009<jats:italic>2)<\/jats:italic>, <jats:italic>AMLS1 (n<\/jats:italic>\u2009=\u2009<jats:italic>1)<\/jats:italic>, <jats:italic>MYBPC3 (n<\/jats:italic>\u2009=\u2009<jats:italic>1)<\/jats:italic>, <jats:italic>PLN<\/jats:italic> (n\u2009=\u20091), and <jats:italic>SCN5A (n<\/jats:italic>\u2009=\u2009<jats:italic>1)<\/jats:italic>. A ring\u2010like septal scar (RLSS) pattern was more often seen in patients with pathogenic variants (66% vs 15%, <jats:italic>p<\/jats:italic>\u2009=\u2009.001). RLSS was associated with deeper seated scars (SDI\u2009&gt;5\u2009mm 30.6\u2009\u00b1\u200922.6% vs 12.4\u2009\u00b1\u200916.2%, <jats:italic>p<\/jats:italic>\u2009=\u2009.005), and increased VT recurrence (HR 5.7 95% CI[1.8\u201018.4], <jats:italic>p<\/jats:italic>\u2009=\u2009.003). After adjustment for age, sex, EF, and total scar burden, the presence of a PV remained independently associated with worse outcomes (HR 4.7 95% CI[1.22\u201018.0], <jats:italic>p<\/jats:italic>\u2009=\u2009.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preprocedural genotyping and scar phenotyping is beneficial to identify patients with a favorable procedural outcome. Some PVs are associated with an intramural, deeper seated scar phenotype and have an increase of VT recurrence after ablation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16039","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T19:40:38Z","timestamp":1692042038000},"page":"1835-1842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Value of genotyping and scar\u2010phenotyping for VT ablation procedures in patients with nonischemic left ventricular cardiomyopathies"],"prefix":"10.1111","volume":"34","author":[{"given":"Boldizsar","family":"Kovacs","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiovascular Medicine University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6951-5238","authenticated-orcid":false,"given":"Michael","family":"Ghannam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiovascular Medicine University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8608-8899","authenticated-orcid":false,"given":"Jackson","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiovascular Medicine University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmeline","family":"Moccoro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiovascular Medicine University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Attili","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7772-5331","authenticated-orcid":false,"given":"Hubert","family":"Cochet","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Helms","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiovascular Medicine University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Latchamsetty","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiovascular Medicine University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krit","family":"Jongnarangsin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiovascular Medicine University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Morady","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiovascular Medicine University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0391-7282","authenticated-orcid":false,"given":"Frank","family":"Bogun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiovascular Medicine University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2020.04.025"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.218.1.r01ja50215"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13130942"},{"key":"e_1_2_9_5_1","first-page":"326","article-title":"Dilated cardiomyopathy and arrhythmogenic left ventricular cardiomyopathy: a comprehensive genotype\u2010imaging phenotype study","volume":"21","author":"Augusto JB","year":"2019","journal-title":"Eur Heart J Cardiovasc 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