{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:54:03Z","timestamp":1788263643440,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Treatment of recurrent atrial fibrillation (AF) is sometimes challenging due to non\u2010pulmonary vein (PV) foci. Fractionated signal area in the atrial muscle (FAAM) is a valid predictor of the location of non\u2010PV foci. FAAM ablation has the potential to decrease the recurrence rate of atrial tachyarrhythmia in patients with recurrent AF. We compared the clinical impact of FAAM ablation for recurrent AF, using 1 year follow up date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 230 consecutive patients with symptomatic recurrent AF who underwent catheter ablation specifically targeting non\u2010PV foci as FAAM\u2010guided ablation (<jats:italic>n<\/jats:italic>\u2009=\u2009113) and non\u2010FAAM\u2010guided ablation (<jats:italic>n<\/jats:italic>\u2009=\u2009117) were retrospectively analyzed. FAAM was assigned a parameter (peaks slider, which indicates the number of components of fractionated signals), ranging from 1 to 15, indicating the location of the FAAM (1: largest, 15: smallest). FAAM\u2010guided ablation was performed by ablating FAAM until none inducibility of non\u2010PV foci. On the other hand, non\u2010FAAM\u2010guided ablation was performed via linear ablation, complex fractionated atrial electrogram ablation, superior vena cava isolation, and focal ablation according to the location of the non\u2010PV foci. The RHYTHMIA system was used to perform all the procedures. The primary endpoints were AF recurrence, atrial flutter, and\/or atrial tachycardia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After a 1\u2010year follow up, freedom from atrial tachyarrhythmia was achieved in 90.3% and 75.2% of patients in the FAAM and non\u2010FAAM groups, respectively (hazard ratio = 0.438 [95% confidence interval: 0.243\u20130.788], <jats:italic>p<\/jats:italic>\u2009\u2009=\u2009\u2009.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FAAM ablation showed a promising decrease in the recurrence rate of atrial tachyarrhythmia in patients with recurrent AF during a 1\u2010year follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16047","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T09:42:17Z","timestamp":1694598137000},"page":"2461-2471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A novel ablation strategy for recurrent atrial fibrillation: Fractionated signal area in the atrial muscle ablation 1\u2010year follow\u2010up"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5588-0533","authenticated-orcid":false,"given":"Jun","family":"Hirokami","sequence":"first","affiliation":[{"name":"Department of Cardiology Kokura Memorial Hospital Kitakyushu Japan"},{"name":"Abteilung fu\u0308r Kardiologie, Cardioangiologisches Centrum Bethanien (CCB), Frankfurt Academy For Arrhythmias (FAFA), Medizinische Klinik III Agaplesion Markus Krankenhaus Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kokura Memorial Hospital Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0230-4556","authenticated-orcid":false,"given":"Masato","family":"Fukunaga","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kokura Memorial Hospital Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Korai","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kokura Memorial Hospital Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Sadohara","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kokura Memorial Hospital Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryogo","family":"Kaimi","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering Kokura Memorial Hospital Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Takeo","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering Kokura Memorial Hospital Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harushi","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering Kokura Memorial Hospital Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kokura Memorial Hospital Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Hiroshima","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kokura Memorial Hospital Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2020.09.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00045415-199903000-00006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14830"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.05.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2021.100717"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408288"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaa293"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.0693"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.120.008667"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrcr.2021.09.010"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12252"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2015.02.020"},{"issue":"42","key":"e_1_2_9_14_1","first-page":"373","article-title":"ESC guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio\u2010Thoracic Surgery (EACTS)","volume":"2021","author":"Hindricks G","year":"2020","journal-title":"Eur Heart J"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad097"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14314"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-020-00913-9"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14576"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd9080249"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaa394"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311081"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(83)90577-5"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.16047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T15:55:15Z","timestamp":1703260515000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.16047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,13]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/jce.16047"],"URL":"https:\/\/doi.org\/10.1111\/jce.16047","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,13]]},"assertion":[{"value":"2023-04-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}