{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:28:13Z","timestamp":1789576093370,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Cardiac resynchronization therapy (CRT) with biventricular pacing (BiV\u2010CRT) is ineffective in approximately one\u2010third of patients. CRT with Conduction system pacing (CSP\u2010CRT) may achieve greater synchronization. We aimed to assess the effectiveness of CRT with His pacing (His\u2010CRT) or left bundle branch pacing (LBB\u2010CRT) in lieu of biventricular CRT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>The PubMed, Embase, Web of Science, Scopus, and the Cochrane Library were systematically searched until August 19, 2023, for original studies including patients with reduced left ventricular ejection fraction (LVEF) who received His\u2010 or LBB\u2010CRT, that reported either CSP\u2010CRT success, LVEF, QRS duration (QRSd), or New York Heart Association (NYHA) classification. Effect measures were compared with frequentist network meta\u2010analysis. Thirty\u2010seven publications, including 20 comparative studies, were included. Success rates were 73.5% (95% CI: 61.2\u201383.0) for His\u2010CRT and 91.5% (95% CI: 88.0\u201394.1) for LBB\u2010CRT. Compared to BiV\u2010CRT, greater improvements were observed for LVEF (mean difference [MD] for His\u2010CRT +3.4%; 95% CI [1.0; 5.7], and LBB\u2010CRT: +4.4%; [2.5; 6.2]), LV end\u2010systolic volume (His\u2010CRT:17.2mL [29.7; 4.8]; LBB\u2010CRT:15.3mL [28.3; 2.2]), QRSd (His\u2010CRT: \u201317.1ms [\u201325.0; \u20139.2]; LBB\u2010CRT: \u201317.4ms [\u201323.2; \u201311.6]), and NYHA (Standardized MD [SMD]: His\u2010CRT:0.4 [0.8; 0.1]; LBB\u2010CRT:0.4 [\u20130.7; \u20130.2]). Pacing thresholds at baseline and follow\u2010up were significantly lower with LBB\u2010CRT versus both His\u2010CRT and BiV\u2010CRT. CSP\u2010CRT was associated with reduced mortality (<jats:italic>R<\/jats:italic>\u2009=\u20090.75 [0.61\u20130.91]) and hospitalizations risk (RR\u2009=\u20090.63 [0.42\u20130.96]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study found that CSP\u2010CRT is associated with greater improvements in QRSd, echocardiographic, and clinical response. LBB\u2010CRT was associated with lower pacing thresholds. Future randomized trials are needed to determine CSP\u2010CRT efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16086","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T08:58:05Z","timestamp":1695891485000},"page":"2342-2359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effectiveness of conduction system pacing for cardiac resynchronization therapy: A systematic review and network meta\u2010analysis"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0244-5914","authenticated-orcid":false,"given":"Hamed","family":"Tavolinejad","sequence":"first","affiliation":[{"name":"Department of Cardiac Electrophysiology, Tehran Heart Center, Cardiovascular Diseases Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2559-0858","authenticated-orcid":false,"given":"Sina","family":"Kazemian","sequence":"additional","affiliation":[{"name":"Department of Cardiac Electrophysiology, Tehran Heart Center, Cardiovascular Diseases Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Bozorgi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Electrophysiology, Tehran Heart Center, Cardiovascular Diseases Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Michalski","sequence":"additional","affiliation":[{"name":"Clinic and Polyclinic for Cardiology, Angiology and Intensive Care, University Hospital Halle Martin\u2010Luther University Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Hoyer","sequence":"additional","affiliation":[{"name":"Clinic and Polyclinic for Cardiology, Angiology and Intensive Care, University Hospital Halle Martin\u2010Luther University Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Sedding","sequence":"additional","affiliation":[{"name":"Clinic and Polyclinic for Cardiology, Angiology and Intensive Care, University Hospital Halle Martin\u2010Luther University Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Arya","sequence":"additional","affiliation":[{"name":"Clinic and Polyclinic for Cardiology, Angiology and Intensive Care, University Hospital Halle Martin\u2010Luther University Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.11.024"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus222"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038648"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2021.04.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.07.019"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2020.08.015"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2022.08.001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.05.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2385"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-2197.2003.02748.x"},{"key":"e_1_2_8_15_1","unstructured":"Higgins JPT Li T Deeks JJ. 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