{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T13:32:12Z","timestamp":1769175132033,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The prospective, nonrandomized, multicenter Q\u2010FFICIENCY study demonstrated the safety and 12\u2010month efficacy of paroxysmal atrial fibrillation (AF) ablation with the novel QDOT MICRO temperature\u2010controlled, contact force\u2010sensing, radiofrequency (RF) catheter. Participants underwent pulmonary vein isolation with very high\u2010power short\u2010duration (vHPSD) mode (90\u2009W, \u22644\u2009s) alone or combined with conventional\u2010power temperature\u2010controlled (CPTC) mode (25\u201350\u2009W). This study aimed to assess quality\u2010of\u2010life (QOL) and healthcare utilization (HCU) benefits experienced by Q\u2010FFICIENCY study participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Besides evaluating procedural efficiency, QOL and HCU were assessed through 12 months postablation via Atrial Fibrillation Effect on Quality\u2010of\u2010Life Tool (AFEQT) score, antiarrhythmic drug (AAD) use, and incidence of cardioversion and cardiovascular hospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 191 participants enrolled, 166 were ablated with the new catheter. Compared to baseline, statistically significant, clinically meaningful improvements in composite and subcategories of AFEQT scores were observed at 3 months and sustained through 12 months (12\u2010month increase, 29.3\u201344.2 points). Class I\/III AAD use decreased from 97.6% (162\/166) at baseline to 19.6% (31\/158) during Months 6\u201312, representing a significant 79.9% reduction. The cardioversion rate significantly declined by 93.9% from 31.3% (12 months preablation) to 1.9% (evaluation period). One\u2010year Kaplan\u2013Meier estimates of freedom from all\u2010cause and cardiovascular hospitalization were 80.9% (95% confidence interval [CI], 74.8%\u201386.9%) and 88.8% (95% CI, 84.0%\u201393.7%), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Paroxysmal AF ablation with the novel temperature\u2010controlled RF catheter in vHPSD mode, alone or with CPTC mode, led to clinically meaningful improvement in QOL and significant reduction in AAD use, cardioversion, and cardiovascular hospitalization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16093","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T11:08:59Z","timestamp":1698059339000},"page":"2493-2503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Paroxysmal atrial fibrillation ablation with a novel temperature\u2010controlled CF\u2010sensing catheter: Q\u2010FFICIENCY clinical and healthcare utilization benefits"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8359-1525","authenticated-orcid":false,"given":"Ayman A.","family":"Hussein","sequence":"first","affiliation":[{"name":"Cleveland Clinic Foundation Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Craig","family":"Delaughter","sequence":"additional","affiliation":[{"name":"Texas Health Heart &amp; Vascular Arlington Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0782-2499","authenticated-orcid":false,"given":"George","family":"Monir","sequence":"additional","affiliation":[{"name":"AdventHealth Orlando Orlando Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5487-0728","authenticated-orcid":false,"given":"Andrea","family":"Natale","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinivas","family":"Dukkipati","sequence":"additional","affiliation":[{"name":"Mount Sinai School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saumil","family":"Oza","sequence":"additional","affiliation":[{"name":"St. Vincent's Medical Center Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3580-2092","authenticated-orcid":false,"given":"Emile","family":"Daoud","sequence":"additional","affiliation":[{"name":"Ohio State University Medical Center Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6508-4047","authenticated-orcid":false,"given":"Luigi","family":"Di Biase","sequence":"additional","affiliation":[{"name":"Montefiore Medical Center at Albert Einstein College of Medicine Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moussa","family":"Mansour","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Fishel","sequence":"additional","affiliation":[{"name":"JFK Medical Center Atlantis Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Valderrabano","sequence":"additional","affiliation":[{"name":"Houston Methodist DeBakey Heart &amp; Vascular Center Houston Methodist Research Institute Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8527-569X","authenticated-orcid":false,"given":"Kenneth","family":"Ellenbogen","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Osorio","sequence":"additional","affiliation":[{"name":"Grandview Medical Center Alabama Cardiovascular Group Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Q\u2010FFICIENCY investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.05.012"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-020-01396-w"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001052"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.0692"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2022.10.019"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.05.063"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2019.04.009"},{"key":"e_1_2_11_10_1","article-title":"Temperature\u2010controlled catheter ablation for paroxysmal atrial fibrillation: the QDOT\u2010MICRO workflow study","volume":"13","author":"De Potter T","year":"2021","journal-title":"J Atr Fibrillation"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.118.005358"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-318676"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2020.04.017"},{"issue":"3","key":"e_1_2_11_14_1","article-title":"Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation","author":"Lafuente\u2010Lafuente C","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000041"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2019422"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaa298"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.110.958165"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013026"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.16093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T15:54:57Z","timestamp":1703260497000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.16093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,23]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/jce.16093"],"URL":"https:\/\/doi.org\/10.1111\/jce.16093","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,23]]},"assertion":[{"value":"2023-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}