{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:43:23Z","timestamp":1784648603580,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Height, left ventricular (LV) size, and sex were proposed as additional criteria for patient selection for cardiac resynchronization therapy (CRT) but their connections with the QRS complex in left bundle branch block (LBBB) are little investigated. We evaluated these.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Among patients with \u201ctrue\u201d LBBB, QRS duration (QRSd) and amplitude, and LV hypertrophy indices, were correlated with patient's height and LV mass, and compared between sexes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this study cohort (<jats:italic>n<\/jats:italic>\u2009=\u2009220; 60\u2009\u00b1\u200912\u2009years; left ventricular ejection fraction [LVEF] 21\u2009\u00b1\u20097%; mostly New York Heart Association II\u2013III, QRSd 165\u2009\u00b1\u200919\u2009ms; 57% female; 70% responders [LVEF increased \u22655%]), LV mass was increased in all patients. QRS amplitude did not correlate with LV mass or height in any individual lead or with Sokolow\u2010Lyon or Cornell\u2010Lyon indices. QRSd did not correlate with height. In contrast, QRSd correlated strongly with LV mass (<jats:italic>r<\/jats:italic>\u2009=\u2009.51). CRT response rate was greater in women versus men (84% vs. 58%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) despite shorter QRSd [7% shorter (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001)]. QRSd normalized for height resulted in a 2.7% and for LV mass 24% greater index in women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>True LBBB criteria do not exclude HF patients with increased LV mass. QRS amplitudes do not correlate with height or LV mass. Height does not affect QRSd. However, QRSd correlates with LV size. QRSd normalized for LV mass results in 24% greater value in women in the direction of sex\u2010specific responses. LV mass may be a significant nonelectrical modifier of QRSd for CRT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16097","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T18:03:44Z","timestamp":1696874624000},"page":"583-591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["LBBB and heart failure\u2014Relationships among QRS amplitude, duration, height, LV mass, and sex"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-9969","authenticated-orcid":false,"given":"Mahesh","family":"Manne","sequence":"first","affiliation":[{"name":"Section of Cardiac Pacing and Electrophysiology, Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0331-9071","authenticated-orcid":false,"given":"Mark","family":"Niebauer","sequence":"additional","affiliation":[{"name":"Section of Cardiac Pacing and Electrophysiology, Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3983-3515","authenticated-orcid":false,"given":"Patrick","family":"Tchou","sequence":"additional","affiliation":[{"name":"Section of Cardiac Pacing and Electrophysiology, Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2296-2596","authenticated-orcid":false,"given":"Niraj","family":"Varma","sequence":"additional","affiliation":[{"name":"Section of Cardiac Pacing and Electrophysiology, Department of Cardiovascular Medicine Cleveland 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