{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T08:13:44Z","timestamp":1758960824881,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T00:00:00Z","timestamp":1699142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Influence of early atrial fibrillation (AF) ablation, particularly cryoballoon ablation (CBA), on clinical outcome during long\u2010term follow\u2010up has not been clarified. The objective was to determine whether an early CBA (diagnosis\u2010to\u2010ablation of \u22646 months) strategy could affect freedom from AF recurrence after index CBA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 2605 patients from Korean CBA registry data with follow\u2010up &gt;12 months after de novo CBA. The primary outcome was recurrence of atrial tachyarrhythmias (ATs) of \u226530\u2010s after a 3\u2010month blanking period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to patients in early CBA group, patients in late CBA group had higher prevalence of diabetes, congestive heart failure, and chronic kidney disease, and higher mean CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VAS score. During mean follow\u2010up of &gt;21 months, ATs recurrence was detected in 839 (32.2%) patients. The early CBA group showed a significantly lower 2\u2010year recurrence rate of ATs than the late CBA group (26.1% vs. 31.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.043). In subgroup analysis, the early CBA group showed significantly higher 1\u2010year and 2\u2010year freedom from ATs recurrence than the late CBA group only in paroxysmal atrial fibrillation (PAF) patients in overall and propensity score matched cohorts. Multivariate analysis showed that early CBA was an independent factor for preventing ATs recurrence in PAF (hazard ratio: 0.637; 95% confidence intervals: 0.412\u20130.984).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early CBA strategy, resulting in significantly lower ATs recurrence during 2\u2010year follow\u2010up after index CBA, might be considered as an initial rhythm control therapy in patients with paroxysmal AF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16122","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T07:32:59Z","timestamp":1699255979000},"page":"69-77","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The impact of early cryoballoon ablation on clinical outcome in patients with atrial fibrillation: From the Korean cryoballoon ablation registry"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8716-1146","authenticated-orcid":false,"given":"Chang Hee","family":"Kwon","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Konkuk University School of Medicine, Konkuk University Medical Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010Hoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Konkuk University School of Medicine, Konkuk University Medical Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Il\u2010Young","family":"Oh","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So\u2010Ryoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital, Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Youn","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Heart Vascular and Stroke Institue, Samsung Medical Center, Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junbeom","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Cardiology, College of Medicine Ewha Womans University Medical Center Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6599-6895","authenticated-orcid":false,"given":"Ki\u2010Hun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Haeundae Paik Hospital, Inje University College of Medicine Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6552-1742","authenticated-orcid":false,"given":"Pil\u2010Sung","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology CHA Bundang Medical Center, CHA University Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Hyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chungnam National University Hospital, Chungnam National University College of Medicine Daejeon 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