{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:59:09Z","timestamp":1791388749650,"version":"4.3.3"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Severe transitory episodes of bradycardia with subsequent syncope in children are common, and generally portend a benign prognosis. Rarely, patients may experience prolonged asystolic episodes secondary to significant sinus pauses (SP)\u00a0or paroxysmal atrioventricular block (AVB).\u00a0Cardioneuroablation (CNA)\u00a0is a catheter\u2010based intervention, used to identify and ablate the epicardial ganglionated plexi (GP),\u00a0which results in disruption of the vagal\u2010mediated parasympathetic input to the sinus and atrioventricular node.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Describe the methodology and role of CNA for treatment of pediatric patients with functional AVB or SP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a single\u2010center, case series study. Patients with SP or AVB, 21 years of age or younger, who underwent CNA between 2015 and 2021 were included. CNA was performed via anatomically guided and high\u2010frequency stimulation methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six patients were included. The median age was 18.9 years (range 12.3\u201320.9 years), 33% female. Two patients had prolonged SP, two had paroxysmal AVB, and two had both SP and AVB. Four patients had prior syncope. The median longest pause was 8.9\u2009s (range 3.9\u201316.8) with 11 total documented pauses (range 2\u2013231) during the 6 months pre\u2010CNA. Post\u2010CNA,\u00a0the median longest pause was 1.3\u2009s (range 0.8\u20132.2) with one documented SP after termination of atrial tachycardia at the 3\u2010month follow\u2010up. At 6 months, the median longest pause was 1.1\u2009s (0.8\u20131.3) with 0 documented pauses. No patients had syncope post\u2010CNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CNA\u00a0may be an effective alternative to pacemaker implantation in pediatric patients with syncope or significant symptoms secondary to functional SP or AVB.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16145","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T17:09:19Z","timestamp":1701450559000},"page":"221-229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cardioneuroablation for pediatric patients with functional sinus node dysfunction and paroxysmal atrioventricular block"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5934-4647","authenticated-orcid":false,"given":"Nak Hyun","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Cardiology Children's National Hospital Washington District of Columbia 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