{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T06:36:07Z","timestamp":1772778967984,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T00:00:00Z","timestamp":1702166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Development of a rapid means to verify the ventricular tachycardia (VT) isthmus location from heart surface electrogram recordings would be a helpful tool for the electrophysiologist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Myocardial infarction was induced in 22 canines by left anterior descending coronary artery ligation under general anesthesia. After\u00a03\u20135 days, VT was inducible via programmed electrical stimulation at the anterior left ventricular epicardial surface. Bipolar VT electrograms were acquired from 196 to 312 recording sites using a multielectrode array. Electrograms were marked for activation time, and activation maps were constructed. The activation signal, or signature, is defined as the cumulative number of recording sites that have activated per millisecond, and it was utilized to segment each circuit into inner and outer circuit pathways, and as an estimate of best ablation lesion location to prevent VT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>VT circuit components were differentiable by activation signals as: inner pathway (mean: 0.30 sites activating\/ms) and outer pathway (mean: 2.68 sites activating\/ms). These variables were linearly related (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Activation signal characteristics were dependent in part upon the isthmus exit site. The inner circuit pathway determined by the activation signal overlapped\u00a0and often extended beyond\u00a0the activation map isthmus location for each circuit. The best lesion location estimated by the activation signal would likely block an electrical impulse traveling through the isthmus, to prevent VT in all circuits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The activation signal algorithm, simple to implement for real\u2010time computer display, approximates the VT isthmus location and shape as determined from activation marking, and best ablation lesion location to prevent reinduction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16146","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T05:32:51Z","timestamp":1702272771000},"page":"267-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Role of activation signatures in re\u2010entrant ventricular tachycardia circuits"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5160-8687","authenticated-orcid":false,"given":"Edward J.","family":"Ciaccio","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiology,\u00a0Columbia University College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"ElectroCardioMaths Programme, Imperial Centre for Cardiac Engineering Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak S.","family":"Saluja","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology,\u00a0Columbia University College of Physicians and Surgeons Columbia University New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas S.","family":"Peters","sequence":"additional","affiliation":[{"name":"ElectroCardioMaths Programme, Imperial Centre for Cardiac Engineering Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6072-5834","authenticated-orcid":false,"given":"Hirad","family":"Yarmohammadi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology,\u00a0Columbia University College of Physicians and Surgeons Columbia University New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2021.104214"},{"issue":"9","key":"e_1_2_8_3_1","first-page":"288","article-title":"Ventricular tachycardia ablation guided by functional substrate mapping: practices and outcomes","volume":"9","author":"V\u00e1zquez\u2010Calvo 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