{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:10:26Z","timestamp":1792642226412,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T00:00:00Z","timestamp":1702771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["514892030"],"award-info":[{"award-number":["514892030"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Pulmonary vein isolation (PVI) using radiofrequency ablation (RFA) is an established treatment strategy for atrial fibrillation (AF). To improve PVI efficacy and safety, high\u2010power short\u2010duration (HPSD) ablation and pulsed\u2010field ablation (PFA) were recently introduced into clinical practice. This study aimed to determine the extent of myocardial injury and systemic inflammation following PFA, HPSD, and standard RFA using established biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 179 patients with paroxysmal AF receiving first\u2010time PVI with different ablation technologies: standard RFA (30\u201340\u2009W\/20\u201330\u2009s, <jats:italic>n<\/jats:italic>\u2009=\u200952), power\u2010controlled HPSD (70\u2009W\/5\u20137\u2009s, <jats:italic>n<\/jats:italic>\u2009=\u200960), temperature\u2010controlled HPSD (90\u2009W\/4\u2009s, <jats:italic>n<\/jats:italic>\u2009=\u200932), and PFA (biphasic, bipolar waveform, <jats:italic>n<\/jats:italic>\u2009=\u200935). High\u2010sensitivity cardiac troponin T (hs\u2010cTnT), creatine kinase (CK),\u00a0CK MB isoform\u00a0(CK\u2010MB), and white blood cell (WBC) count were determined before and after ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline characteristics were well\u2010balanced between groups (age 63.1\u2009\u00b1\u200910.3 years, 61.5% male). Postablation hs\u2010cTnT release was significantly higher with PFA (1469.3\u2009\u00b1\u2009495.0\u2009ng\/L), HPSD\u201070W (1322.3\u2009\u00b1\u2009510.6\u2009ng\/L), and HPSD\u201090W (1441.2\u2009\u00b1\u2009409.9\u2009ng\/L) than with standard RFA (1045.9\u2009\u00b1\u2009369.7\u2009ng\/L; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). CK and CK\u2010MB release was increased with PFA by 3.4\u2010fold and 5.8\u2010fold, respectively, as compared to standard RFA (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). PFA was associated with the lowest elevation in WBC (\u03941.5\u2009\u00b1\u20091.5\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L), as compared to standard RFA (\u03943.8\u2009\u00b1\u20092.5\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), HPSD\u201070W (\u03942.7\u2009\u00b1\u20091.7\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L, <jats:italic>p<\/jats:italic>\u2009=\u2009.037), and HPSD\u201090W (\u03943.6\u2009\u00b1\u20092.5\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among the four investigated ablation technologies, PFA was associated with the highest myocardial injury and the lowest inflammatory reaction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16157","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T04:36:02Z","timestamp":1702874162000},"page":"317-327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Myocardial injury and inflammation following pulsed\u2010field ablation and very high\u2010power short\u2010duration ablation for atrial fibrillation"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9308-2492","authenticated-orcid":false,"given":"Miruna A.","family":"Popa","sequence":"first","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical University of Munich Munich Germany"},{"name":"Munich Arrhythmia Research and Study Center (MARS) German Heart Center Munich Munich Germany"},{"name":"Department of Cardiac Pacing and Electrophysiology H\u00f4pital Cardiologique du Haut\u2010L\u00e9v\u00eaque, CHU de Bordeaux Pessac France"},{"name":"IHU LIRYC, Electrophysiology and Heart Modeling Institute Fondation Bordeaux Universit\u00e9 &amp; INSERM\u2014U1045 University of Bordeaux Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Bahlke","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical University of Munich Munich Germany"},{"name":"Munich Arrhythmia Research and Study Center (MARS) German Heart Center Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7742-5598","authenticated-orcid":false,"given":"Marc","family":"Kottmaier","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical University of Munich Munich Germany"},{"name":"Munich Arrhythmia Research and Study Center (MARS) German Heart Center Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie","family":"Foerschner","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical University of Munich Munich Germany"},{"name":"Munich Arrhythmia Research and Study Center (MARS) German Heart Center Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4861-6595","authenticated-orcid":false,"given":"Felix","family":"Bourier","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical University of Munich Munich Germany"},{"name":"Munich Arrhythmia Research and Study Center (MARS) German Heart Center Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lengauer","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical 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