{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T22:31:44Z","timestamp":1778106704798,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The utility of ablation index (AI) to guide ventricular tachycardia (VT) ablation in patients with structural heart disease is unknown. The aim of this study was to assess procedural characteristics and clinical outcomes achieved using AI\u2010guided strategy (target value 550) or conventional non\u2010AI\u2010guided parameters in patients undergoing scar\u2010related VT ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients (<jats:italic>n<\/jats:italic>\u2009=\u2009103) undergoing initial VT ablation at a single center from 2017 to 2022 were evaluated. Patient groups were 1:1 propensity\u2010matched for baseline characteristics. Single lesion characteristics for all 4707 lesions in the matched cohort (<jats:italic>n<\/jats:italic>\u2009=\u200974) were analyzed. The impact of ablation characteristics was assessed by linear regression and clinical outcomes were evaluated by Cox proportional hazard model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After propensity\u2010matching, baseline characteristics were well\u2010balanced between AI\u00a0(<jats:italic>n<\/jats:italic>\u2009=\u200937) and non\u2010AI\u00a0(<jats:italic>n<\/jats:italic>\u2009=\u200937) groups. Lesion sets were similar (scar homogenization [41% vs. 27%;\u00a0<jats:italic>p<\/jats:italic>\u2009=\u2009.34], scar dechanneling [19% vs. 8%;\u00a0<jats:italic>p<\/jats:italic>\u2009=\u2009.18], core isolation [5% vs.\u00a011%;\u00a0<jats:italic>p<\/jats:italic>\u2009=\u2009.4],\u00a0linear and elimination late potentials\/local abnormal ventricular activities\u00a0[35% vs. 44%;\u00a0<jats:italic>p<\/jats:italic>\u2009=\u2009.48], epicardial mapping\/ablation [11% vs.\u00a014%;\u00a0<jats:italic>p<\/jats:italic>\u2009=\u2009.73]). AI\u2010guided strategy had 21% lower procedure duration (\u221247.27\u2009min, 95% confidence interval\u00a0[CI]\u00a0[\u221281.613, \u221212.928];\u00a0<jats:italic>p<\/jats:italic>\u2009=\u2009.008), 49% lower radiofrequency time per lesion (\u221213.707\u2009s, 95%\u00a0CI\u00a0[\u221217.86, \u22129.555];\u00a0<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), 21% lower volume of fluid administered (1664\u2009cc\u00a0[1127, 2209] vs. 2126\u2009cc [1750, 2593];\u00a0<jats:italic>p<\/jats:italic>\u2009=\u2009.005). Total radiofrequency duration (\u2212339 s [\u221224%], 95%CI\u00a0[\u2212776, 62];\u00a0<jats:italic>p<\/jats:italic>\u2009=\u2009.09) and steam pops (\u2212155.6%, 95%\u00a0CI\u00a0[19.8%,\u00a0\u2212330.9%];\u00a0<jats:italic>p<\/jats:italic>\u2009=\u2009.08) were nonsignificantly lower in the AI group. Acute procedural success (95% vs.\u00a089%;\u00a0<jats:italic>p<\/jats:italic>\u2009=\u2009.7) and VT recurrence (0.97, 95% CI\u00a0[0.42\u20132.2];\u00a0<jats:italic>p<\/jats:italic>\u2009=\u2009.93) were similar for both groups. Lesion analysis (<jats:italic>n<\/jats:italic>\u2009=\u20094707) demonstrated a plateau in the magnitude of impedance drops once reaching an AI of 550\u2013600.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this pilot study, an AI\u2010guided ablation strategy for scar\u2010related VT resulted in shorter procedure time and average radiofrequency time per lesion with similar acute procedural and intermediate\u2010term clinical outcomes to a non\u2010AI\u2010guided approach utilizing traditional ablation parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16165","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T12:44:06Z","timestamp":1704372246000},"page":"625-638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Surpoint algorithm for improved guidance of ablation for ventricular tachycardia (SURFIRE\u2010VT): A pilot study"],"prefix":"10.1111","volume":"35","author":[{"given":"David","family":"Sanders","sequence":"first","affiliation":[{"name":"Department of Cardiology Rush University Medical Center Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne M.","family":"Du\u2010Fay\u2010de\u2010Lavallaz","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Winterfield","sequence":"additional","affiliation":[{"name":"Department of Cardiology Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0023-9666","authenticated-orcid":false,"given":"Pasquale","family":"Santangeli","sequence":"additional","affiliation":[{"name":"Department of Cardiology Cleveland Clinic Cleveland Ohio 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