{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:52:02Z","timestamp":1789732322202,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Despite advanced ablation strategies and major technological improvements, treatment of persistent atrial fibrillation (AF) remains challenging and the underlying pathophysiology is not fully understood. This study analyzed the multiple procedure outcome and safety of catheter ablation of spatiotemporal dispersions (DISPERS) detected by artificial intelligence (AI)\u2010guided software in patients with long\u2010standing persistent AF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      The Volta VX1 software was used for 50 consecutive patients undergoing catheter ablation for persistent AF. First, high\u2010density mapping (78% biatrial) with a multipolar mapping catheter was performed. In addition to pulmonary vein isolation (PVI), ablation of DISPERS was performed aiming at homogenizing, dissecting, isolating, or connecting DISPERS areas to nonconducting anatomical structures. Follow\u2010up contained regular visits at our outpatient clinic at 1, 3, 6, and 12 months including 7\u2010day Holter electrocardiograms. Patients were mainly suffering from long\u2010standing persistent AF (mean AF duration 50.30\u2009\u00b1\u200954.28 months). Following PVI, ablation of left atrial and right atrial DISPERS areas led to AF cycle length prolongation (mean of 162.0\u2009\u00b1\u200916.6\u00a0to 202.2\u2009\u00b1\u200921.6\u2009ms after) and AF termination to atrial tachycardia (AT) or sinus rhythm (SR) in 12 patients (24%). No stroke or pericardial effusion occurred; major groin complications (pseudoaneurysm\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091, atrioventricular\u00a0fistula\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091) were detected in two patients. After a blanking period of 6 weeks, recurrence of any atrial arrhythmia was documented in 26 patients (52%). The majority of patients presented with organized AT (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915) while AF was present in\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099 patients and AT\/AF was observed in\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092 patients. Twenty\u2010two\u00a0patients underwent reablation. During a mean follow\u2010up of 363.14\u2009\u00b1\u2009187.42 days and after an average of 1.46\u2009\u00b1\u20090.68 procedures, 82% of patients remained in stable SR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DISPERS\u2010guided ablation using machine learning software (the Volta VX1 software) in addition to PVI in long\u2010standing persistent AF ablation resulted in high long\u2010term success rates regarding AF and AT elimination. Most arrhythmia recurrences were reentrant AT. After a total of 1.46\u2009\u00b1\u20090.68 procedures, freedom from AF\/AT was 82%. Despite prolonged procedure times complication rates were low. Randomized studies are necessary to evaluate long\u2010term efficacy of dispersion\u2010guided ablation using AI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.16184","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T06:58:38Z","timestamp":1704869918000},"page":"406-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["First clinical data on artificial intelligence\u2010guided catheter ablation in long\u2010standing persistent atrial fibrillation"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6265-5403","authenticated-orcid":false,"given":"Fabian","family":"Bahlke","sequence":"first","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Englert","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9308-2492","authenticated-orcid":false,"given":"Miruna","family":"Popa","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4861-6595","authenticated-orcid":false,"given":"Felix","family":"Bourier","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilko","family":"Reents","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1693-6474","authenticated-orcid":false,"given":"Carsten","family":"Lennerz","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Kraft","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex Tunsch","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7742-5598","authenticated-orcid":false,"given":"Marc","family":"Kottmaier","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Syv\u00e4ri","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Tydecks","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Telishevska","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lengauer","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Hessling","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5826-6846","authenticated-orcid":false,"given":"Isabel","family":"Deisenhofer","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Erhard","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, German Heart Center Munich Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux274"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408288"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602014"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.01.017"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2010.01798.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.23722"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2200141"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15657"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.10.065"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac116"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.04.060"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2010.01786.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40119-022-00273-7"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw260"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.114.001672"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac089"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac215"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac190"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.16184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T06:05:32Z","timestamp":1709791532000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.16184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,10]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/jce.16184"],"URL":"https:\/\/doi.org\/10.1111\/jce.16184","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,10]]},"assertion":[{"value":"2023-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}