{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:06:35Z","timestamp":1785150395650,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cardioneuroablation (CNA) is a novel therapeutic approach for functional bradyarrhythmias, specifically neurocardiogenic syncope or atrial fibrillation, achieved through endocardial radiofrequency catheter ablation of vagal innervation, obviating the need for pacemaker implantation. Originating in the nineties, the first series of CNA procedures was published in 2005. Extra\u2010cardiac vagal stimulation (ECVS) is employed as a direct method for stepwise denervation control during CNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to compare the long\u2010term follow\u2010up outcomes of patients with severe cardioinhibitory syncope undergoing CNA with and without denervation confirmation via ECVS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A cohort of 48 patients, predominantly female (56.3%), suffering from recurrent syncope (5.1\u2009\u00b1\u20092.5 episodes annually) that remained unresponsive to clinical and pharmacological interventions, underwent CNA, divided into two groups: ECVS and NoECVS, consisting of 34 and 14 cases, respectively. ECVS procedures were conducted with and without atrial pacing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Demographic characteristics, left atrial size, and ejection fraction displayed no statistically significant differences between the groups. Follow\u2010up duration was comparable, with 29.1\u2009\u00b1\u200915 months for the ECVS group and 31.9\u2009\u00b1\u200920 months for the NoECVS group (<jats:italic>p<\/jats:italic>\u2009=\u2009.24). Notably, syncope recurrence was significantly lower in the ECVS group (two cases vs. four cases, Log Rank <jats:italic>p<\/jats:italic>\u2009=\u2009.04). Moreover, the Hazard ratio revealed a fivefold higher risk of syncope recurrence in the NoECVS group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates that concluding CNA with denervation confirmation via ECVS yields a higher success rate and a substantially reduced risk of syncope recurrence compared to procedures without ECVS confirmation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16188","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T12:06:15Z","timestamp":1705665975000},"page":"641-650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Long\u2010term outcomes of cardioneuroablation with and without extra\u2010cardiac vagal stimulation confirmation in severe cardioinhibitory neurocardiogenic syncope"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5111-488X","authenticated-orcid":false,"given":"Jose Carlos","family":"Pachon\u2010M","sequence":"first","affiliation":[{"name":"Sao Paulo University Sao Paulo Brazil"},{"name":"Sao Paulo Heart Hospital Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique I.","family":"Pachon\u2010M","sequence":"additional","affiliation":[{"name":"Sao Paulo University Sao Paulo Brazil"},{"name":"Sao Paulo Heart Hospital Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos T. C.","family":"Pachon","sequence":"additional","affiliation":[{"name":"Sao Paulo Heart Hospital Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas G.","family":"Santillana\u2010P","sequence":"additional","affiliation":[{"name":"Sao Paulo Heart Hospital Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasso J.","family":"Lobo","sequence":"additional","affiliation":[{"name":"Sao Paulo Heart Hospital Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Pachon\u2010M","sequence":"additional","affiliation":[{"name":"Sao Paulo University Sao Paulo Brazil"},{"name":"Sao Paulo Heart Hospital Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Higuti","sequence":"additional","affiliation":[{"name":"Sao Paulo Heart Hospital Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan 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