{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:38:22Z","timestamp":1773200302263,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Most patients with Brugada syndrome (BrS) are first diagnosed in their 40s, with sudden cardiac death (SCD) often occurring in their 50s. Ventricular fibrillation (VF) may occur in some patients with BrS despite having been asymptomatic for a long period. This study aimed to assess the incidence and risk factors for late life\u2010threatening arrhythmias in patients with BrS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with BrS (<jats:italic>n<\/jats:italic>\u2009=\u2009523; mean age, 51\u2009\u00b1\u200913 years; male, <jats:italic>n<\/jats:italic>\u2009=\u2009497) were enrolled. The risk of late life\u2010threatening arrhythmia was investigated in 225 patients who had experienced no cardiac events (CEs: SCD or ventricular tachyarrhythmia) for at least 10 years after study enrollment. The incidence of CEs during the follow\u2010up period was examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the follow\u2010up of the 523 patients, 59 (11%) experienced CEs. The annual incidences of CEs were 2.87%, 0.77%, and 0.09% from study enrollment to 3, 3\u221210, and after 10 years, respectively. Among 225 patients who had experienced no CEs for at least 10 years after enrollment, four\u00a0patients (1.8%) subsequently experienced CEs. Kaplan\u2013Meier analysis revealed significant differences in the incidence of late CEs between patients with and without a history of symptoms (<jats:italic>p<\/jats:italic>\u2009=\u2009.032). The positive and negative predictive values of late CEs for the programmed electrical stimulation (PES) test were 2.9% and 100%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that patients with BrS who are asymptomatic and have no ventricular tachycardia\/VF inducibility by PES are at extremely low risk of experiencing late life\u2010threatening arrhythmias.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16205","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T12:43:55Z","timestamp":1707396235000},"page":"701-707","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Late life\u2010threatening arrhythmia in patients with Brugada syndrome: Results from long\u2010term follow\u2010up in a large Japanese cohort"],"prefix":"10.1111","volume":"35","author":[{"given":"Tetsuji","family":"Shinohara","sequence":"first","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine Oita University Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Medicine II Kansai Medical University Moriguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2964-2544","authenticated-orcid":false,"given":"Tsukasa","family":"Kamakura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Division of Arrhythmia and Electrophysiology National Cerebral and Cardiovascular Center Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyasu","family":"Aizawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Internal Medicine Sakakibara Heart Institute Fuchu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology Daisan Kitashinagawa Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohiko","family":"Aihara","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Senri Central Hospital Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayasu","family":"Hiraoka","sequence":"additional","affiliation":[{"name":"Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Aonuma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Japan Idiopathic Ventricular Fibrillation Study (J\u2010IVFS) Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.05.024"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.887026"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01421-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.12.031"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00204"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.11.067"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux096"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.12.023"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.12491"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.114.002705"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-0221"},{"key":"e_1_2_8_13_1","first-page":"102","article-title":"Testosterone levels in an aging population: screen, measure, and restore","volume":"15","author":"Kells J","year":"2011","journal-title":"Int\u00a0J\u00a0Pharmaceu\u00a0Compounding"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.064"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2003.02517.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq381"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.017885"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.08.862"}],"container-title":["Journal of Cardiovascular 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